Abstract
CARBOXYPEPTIDASE can split from peptide chains those terminal amino-acids that carry a free α-carboxyl group. The enzyme was used by Grassman et al.1 in demonstrating that the C-terminal residue of glutathione is glycine, and by Lens2 in studying the C-terminal residues of the peptide chains of insulin. Lens found that alanine is the end-group in two of the four chains of insulin, but was unable to identify the end-groups of the other two chains.
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References
Grassman, W., Dycherhoff, H., and Eibeler, H., Z. phys. Chem., 189, 112 (1930).
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THOMPSON, A. The C-Terminal Residue of Lysozyme. Nature 169, 495–496 (1952). https://doi.org/10.1038/169495a0
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DOI: https://doi.org/10.1038/169495a0
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