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Separation of Coombs Reagent into Two Fractions

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Abstract

IT was shown by Dacie1 that normal human sera contain what appears to be an incomplete antibody which becomes attached to erythrocytes at 4' C. and which can be demonstrated by the antiglobulin technique of Coombs. It appears, however, that the substance in the Coombs reagent (rabbit anti-human globulin serum) involved in the reaction is distinct from that involved in the agglutination by Coombs reagent of red cells sensitized by incomplete Rh antibodies, since the Coombs reagent can be separated into two fractions by absorption with suitably sensitized cells.

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References

  1. Dacie, J. V., Nature, 166, 36 (1950).

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  2. Witebsky, E., Blood (Spec. Issue No. 2), 66 (1948).

  3. Stratton, F., and Renton, P. H. (unpublished observations).

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Authors and Affiliations

  1. National Blood Transfusion Centre, Roby Street, Manchester, 1

    P. H. RENTON

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  1. P. H. RENTON
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RENTON, P. Separation of Coombs Reagent into Two Fractions. Nature 169, 329–330 (1952). https://doi.org/10.1038/169329b0

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