Skip to main content
SpringerLink
Log in

Identification of a Heparin as a Main Component of the ‘Third Factor’ involved in the Virulence-enhancing Action of Hog Gastric Mucin

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

PREVIOUS work1–4 has shown that the virulence-enhancing action of hog gastric mucin is due to a synergic action between two non-specific factors (a viscous medium and particulate residue), and a more specific soluble third factor. Partial purification of the latter3 yielded a heterogeneous product which was predominantly peptide in nature, but which contained 5–10 per cent of carbohydrate residues. Further purification, using a revised assay4 in which the two non-specific factors are maintained constant, has shown that the carbohydrate moiety is responsible for the activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Smith, H., Biochem. J., 46, 352 (1950).

    Article  CAS  Google Scholar 

  2. Smith, H., Biochem. J., 46, 356 (1950).

    Article  CAS  Google Scholar 

  3. Smith, H., Biochem. J., 48, 441 (1951).

    Article  CAS  Google Scholar 

  4. Smith, H., Stanley, J. L., and Harris-Smith, P. W., Biochem. J. (in the press).

  5. Dische, Z., J. Biol. Chem., 167, 189 (1947).

    CAS  PubMed  Google Scholar 

  6. Jorpes, J. E., and Gardell, S., J. Biol. Chem., 176, 267 (1948).

    CAS  Google Scholar 

  7. Ecker, E. E., and Gross, P., J. Infect. Dis., 44, 250 (1929).

    Article  CAS  Google Scholar 

  8. Reinert, M., and Winterstein, A., Arch. intern. pharmaco-dynamie, 62, 47 (1939).

    CAS  Google Scholar 

  9. Wolfrom, M. L., Weisblat, L. I., Karabinos, J. V., McNeely, W. H., and McLean, J., J. Amer. Chem. Soc., 65, 2077 (1943).

    Article  CAS  Google Scholar 

  10. Jorpes, J. E., Boström, H., and Mutt, V., J. Biol. Chem., 183, 607 (1950).

    CAS  Google Scholar 

  11. Elson, L. A., and Morgan, W. T. J., Biochem. J., 27, 1824 (1933).

    Article  CAS  Google Scholar 

  12. Jorpes, E., Biochem. J., 29, 1817 (1935).

    Article  CAS  Google Scholar 

  13. Jorpes, E., Biochem. J., 36, 203 (1942).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Microbiological Research Department, Porton, Wilts

    H. SMITH

Authors
  1. H. SMITH
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SMITH, H. Identification of a Heparin as a Main Component of the ‘Third Factor’ involved in the Virulence-enhancing Action of Hog Gastric Mucin. Nature 168, 563–564 (1951). https://doi.org/10.1038/168563a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/168563a0

  • Springer Nature Limited

This article is cited by

Search

Navigation