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A 2 : 4-Diamino Pyrimidine in the Treatment of Proguanil-resistant Laboratory Malarial Strains

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Abstract

A SERIES of 2 : 4-diamino pyrimidines substituted in the 5- and/or 6-position has recently been described1 as having activity against malaria infections of laboratory animals. In particular, 2 : 4-diamino-5-p-chlorophenyl-6-ethyl pyrimidine (I), termed 50–63 here, showed a high degree, of activity. This compound has been tested against strains of malaria parasites showing experimentally induced resistance to proguanil. Its activity against these resistant strains falls little short of that which it exercises against normal strains.

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Authors and Affiliations

  1. Wellcome Laboratories of Tropical Medicine, Euston Road, London, N.W.1

    I. M. ROLLO

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  1. I. M. ROLLO
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ROLLO, I. A 2 : 4-Diamino Pyrimidine in the Treatment of Proguanil-resistant Laboratory Malarial Strains. Nature 168, 332–333 (1951). https://doi.org/10.1038/168332b0

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