Abstract
DURING recent studies on carbohydrate metabolism in shock, we have examined the citrate-level in the kidney of the fasting rat by Buffa and Peters's modification1 of the method of Pucher, Sherman and Vickery2, during the shock state produced by the parenteral injection of nucleotides. A marked increase (P = 0.01) in the citrate content of the kidney occurred 1 hr. after the intraperitoneal injection of a lethal dose of adenosinetriphosphate (250 mgm. magnesium adenosinetriphosphate per 100 gm. body-weight in the strain of rat used, at an environmental temperature of 18–22° C.; see table). This increase was not maintained, and 4 hr. after the injection the level had returned to normal. In its time relationships this effect resembles that seen in fluoro-acetate poisoning; but in the latter condition the increase in the citrate content of the rat kidney is much greater1,3.
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References
Buffa, P., and Peters, R. A., J. Physiol., 110, 488 (1950).
Pucher, G. W., Sherman, C. C., and Vickery, H. B., J. Biol. Chem., 113, 235 (1936).
Potter, V. R., and Busch, H., Cancer Res., 10, 353 (1950).
Stoner, H. B., Green, H. N., and Threlfall, C. J., XVIII Int. Physiol. Congress, 473 (1950).
Stoner, H. B., Green, H. N., and Threlfall, C. J. (in preparation).
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THRELFALL, C., STONER, H. & GREEN, H. Kidney Citrate Levels in Nucleotide Shock. Nature 168, 297–298 (1951). https://doi.org/10.1038/168297a0
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DOI: https://doi.org/10.1038/168297a0
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