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Chromosome Alteration and Tumour Inhibition by Nitrogen Mustards: the Hypothesis of Cross-linking Alkylation

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Abstract

IN the foregoing communication, attention is directed to the ability of certain monofunctional alkylating agents to produce chromosome damage and inhibition of tumour growth. Similar cytological observations have been made in this Institute1.

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References

  1. Ann. Rep. Brit. Emp. Cancer Campaign for 1949, pp. 39, 46.

  2. Philips, F. S., J. Pharm. Exp. Ther., 99, 281 (1950).

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  3. Haddow, A. (unpublished work).

  4. Rapoport, I. A., Dok. Akad. Nauk S.S.S.R., 60, 469 (1948).

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  5. Bird, M., paper read before the Genetical Society Symposium on Biochemical Genetics (London, 1950).

  6. Rapoport, I. A., Bull. Exp. Biol. Med. U.S.S.R., 23, 3 (1947).

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LOVELESS, A., ROSS, W. Chromosome Alteration and Tumour Inhibition by Nitrogen Mustards: the Hypothesis of Cross-linking Alkylation. Nature 166, 1113–1114 (1950). https://doi.org/10.1038/1661113a0

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