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Chromatography of Nucleic Acid Derivatives

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Abstract

THE nucleic acids and their derivatives are fundamental constituents of biological systems ; but until recently workers have lacked precise micro methods for their study. Vischer and Chargaff1, and recently Hotchkiss2 and also Reichard3, have shown that partition chromatography4 may be used to separate and characterize certain derivatives. The methods employed by these workers to detect the spots on the chromatograms were, however, either limited in their scope or necessitated the analysis of a large number of fractions selected arbitrarily from the columns.

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References

  1. Vischer, E., and Chargaff, E., J. Biol. Chem., 168, 781 (1947).

    CAS  PubMed  Google Scholar 

  2. Hotchkiss, R. D., J. Biol. Chem. 175, 315 (1938).

    Google Scholar 

  3. Reichard, P., Nature, 162, 662 (1948).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Consden, R., Gordon, A. H., and Martin, A. J. P., Biochem. J., 38, 224 (1944).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Bowen, E. J., "Chemical Aspects of Light" (Clarendon Press, Oxford 1946).

    Book  Google Scholar 

  6. Levene, P. A., and Bass, L. W., "Nucleic Acids" (The Chemical Catalog Co., Inc., New York, 1931).

    Google Scholar 

  7. Bredereck, H., Martini, A., and Richter, F., Ber. deutsch. chem. Ges., 74, 694 (1941).

    Article  Google Scholar 

  8. Graff, S., and Maculla, A., J. Biol. Chem., 110, 71 (1935).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Agricultural Research Council, Plant Virus Research Unit, Molteno Institute, Cambridge

    ROY MARKHAM & JOHN D. SMITH

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  1. ROY MARKHAM
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  2. JOHN D. SMITH
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MARKHAM, R., SMITH, J. Chromatography of Nucleic Acid Derivatives. Nature 163, 250–251 (1949). https://doi.org/10.1038/163250b0

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