Abstract
IN the course of work primarily concerned with the biological action of carcinogens, it was found that various sulphuric acid derivatives of large-molecule hydrocarbons strikingly inhibited certain enzyme systems when tested in Warburg respiro-meters. Substances I, II, III and IV (see over) inhibited the pyruvate-triose-phosphate system of rabbit skeletal muscle1 by 87, 95, 94 and 50 per cent respectively, and the oxaloacetate-triosephosphate system of the same preparation by 68, 70, 53 and 10 per cent when added at M/500 in presence of 1/150 per cent extra cozymase. With extra cozymase the inhibition was decreased. It appeared to be competitive. Substance V was almost inactive at this concentration.
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References
Green, D. E., Needham, D. M., and Dewan, J., Biochem. J., 31, 2327 (1937).
Quastel, J. H., and Wheatley, A. H. M., Biochem. J., 32, 936 (1938).
Straub, F. B., Biochem. J., 34, 484 (1940).
Crabtree, H. G., Cancer Research, 2, 405 (1941).
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HOCKENHULL, D. Inhibition of some Respiratory Enzyme Systems by Derivatives of Sulphuric Acid. Nature 162, 813–814 (1948). https://doi.org/10.1038/162813b0
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DOI: https://doi.org/10.1038/162813b0
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