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Synthesis of Derivatives of N-Methyl-2-Pyridone from Nicotinic Acid and Nicotinamide

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Abstract

IT is well known that N-methylnicotinamide is formed from nicotinamide by methylation in the human body, and Knox and Grossman1,2 have shown that N-methylnicotinamide is itself capable of being metabolized. These workers not only demonstrated that N-methylnicotinamide could be oxidized to N-methyl-2-pyridone-5-carboxylamide by an enzyme present in rabbit liver ; but they also succeeded in isolating the latter compound from human urine after the ingestion of doses of 0·6–0·9 gm. of nicotinamide per day.

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Authors and Affiliations

  1. Farbenfabriken Bayer, Wuppertal-Elberfeld

    CHR. WIEGAND

  2. Medical Research Council, Department of Experimental Medicine, University of Cambridge,

    W. I. M. HOLMAN

Authors
  1. CHR. WIEGAND
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  2. W. I. M. HOLMAN
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WIEGAND, C., HOLMAN, W. Synthesis of Derivatives of N-Methyl-2-Pyridone from Nicotinic Acid and Nicotinamide. Nature 162, 659–660 (1948). https://doi.org/10.1038/162659a0

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