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Functional integration of neural grafts in Parkinson's disease

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Abstract

Functional imaging in a Parkinson's patient with a neural transplant shows that the graft is still functional after ten years, and that dopamine from the graft can bind to postsynaptic sites.

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Figure 1: Schematic illustration of the normal dopamine terminal in the basal ganglia, the pre- and postsynaptic changes associated with PD and cell transplantation, and the sites of accumulation of the two PET ligands, [18F]dopa and [11C]raclopride (see text for details).

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Authors and Affiliations

  1. Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK

    Roger A Barker & Stephen B. Dunnett

Authors
  1. Roger A Barker
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  2. Stephen B. Dunnett
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Barker, R., Dunnett, S. Functional integration of neural grafts in Parkinson's disease. Nat Neurosci 2, 1047–1048 (1999). https://doi.org/10.1038/15969

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