Abstract
NOLAN and his co-workers have described1,2,3 the isolation from the lichen Buellia canescens, of diploicin, and from constitutional studies have provisionally assigned to it structure I. Diploicin is insoluble in water, and for this reason its antibacterial activity was not examined by us in vitro. Iodinated and chlorinated phenyl ethers of type II have been shown, however, by Burger, Brindley, Wilson and Bernheim4 to have tuberculostatic activity in vitro. A closer study of the diploicin molecule was, therefore, considered desirable.
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References
Nolan, Sci. Proc. Roy. Dub. Soc., 21, 67 (1935).
Spillane, Keane and Nolan, Sci. Proc. Roy. Dub. Soc., 21, 333 (1936).
Davidson, Keane and Nolan, Sci. Proc. Roy. Dub. Soc., 23, 151 (1943).
Burger, Brindley, Wilson and Bernheim, J. Amer. Chem. Soc., 67 1416 (1945).
Rich, “The Pathogenesis of Tuberculosis” (Thomas, Springfield, Illinois, 1944).
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BARRY, V. The Thyroid and Tuberculosis. Nature 158, 131–132 (1946). https://doi.org/10.1038/158131d0
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DOI: https://doi.org/10.1038/158131d0
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