Abstract
GLI proteins control cell fate, growth and patterning. In unstimulated cells, several mechanisms ensure the active repression of GLI target genes. Hedgehog signalling switches on a sensitive activation programme through coordinate effects on GLI proteins, resulting in nuclear accumulation of transcriptionally active GLI forms.
References
Ruiz i Altaba, A. Trends Genet. 15, 418–425 (1999)
Kogerman, P. et al. Nature Cell Biol. 1, 312– 319 (1999).
Chen, Y. et al. Development 126, 3607–3616 (1999).
Chen, C.-H. et al. Cell 98, 305–316 (1999).
Pearse, R. V. et al. Dev. Biol. 212, 323– 336 (1999).
Aza-Blanc, P. et al. Cell 89, 1043–1053 (1997).
Robbins, D. J. et al. Cell 90, 225–234 (1997).
Sisson, J. C. et al. Cell 90, 235–245 (1999).
Monnier, V. et al. Curr. Biol. 8, 583– 386 (1998).
Ohlmeyer, J. T. & Kalderon, D. Nature 396, 749–753 (1999).
Methot, N. & Basler, K. Cell 96, 819 –831 (1999).
Ruiz i Altaba, A. Development 126, 3205–3219 (1999).
Sasaki, H. et al. Development 126, 3915– 3924 (1999).
Shin, S. H. et al. Proc. Natl Acad. Sci. USA 96, 2880– 2884 (1999).
Chuang, P. & McMahon, A. P. Nature 397, 617–621 (1999).
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Ruiz i Altaba, A. The works of GLI and the power of Hedgehog. Nat Cell Biol 1, E147–E148 (1999). https://doi.org/10.1038/14099
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DOI: https://doi.org/10.1038/14099
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