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NSF is up to new tricks

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Abstract

Membrane trafficking depends on NSF, an ATPase that dissociates a complex of membrane proteins called SNAREs. A particular NSF mutant apparently lacks ATPase activity and cannot dissociate SNAREs, but can still promote membrane fusion in an in vitro assay. Might NSF, in certain systems, have actions we do not yet appreciate?

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Figure 1: Four models of NSF function in the fusion of a vesicle and its target membrane.

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Authors and Affiliations

  1. Department of Molecular and Cellular Physiology, School of Medicine, Beckman Center, Stanford University Medical Center, Stanford, 94305-5345 , California, USA

    Thomas L. Schwarz

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  1. Thomas L. Schwarz
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Correspondence to Thomas L. Schwarz.

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Schwarz, T. NSF is up to new tricks. Nat Cell Biol 1, E141–E142 (1999). https://doi.org/10.1038/14090

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