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The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

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Figure 1: Cbfb-MYH11 blocks myeloid and lymphoid differentiation.
Figure 2: Development of acute myelomonocytic leukaemia in ENU-treated Cbfb+/Cbfb-MYH11 chimaeras.

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Acknowledgements

We thank A.R. Moser for advice on the ENU mutagenesis; F. Collins and L. Brody for critical reading of the manuscript; S. Hoogstraten-Miller, A. Cheng and T. Hernendez for technical assistance; and T. Blake, K. Henning and S. Lyons for helpful discussions.

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Authors and Affiliations

  1. Genetics and Molecular Biology Branch,, Bethesda, 20892, Maryland, USA

    Lucio H. Castilla, Neeraj Adya, Donald Orlic, Stacie Anderson, David Bodine & P. Paul Liu

  2. Genetic Disease Research Branch, National Human Genome Research Institute,, Bethesda, 20892, Maryland, USA

    Lisa Garrett & Amalia Dutra

  3. Veterinary Resources Program, National Institutes of Health,, Bethesda, 20892, Maryland, USA

    Jennie Owens &  Michael Eckhaus

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  1. Lucio H. Castilla
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  2. Lisa Garrett
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  9. David Bodine
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  10. P. Paul Liu
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Correspondence to P. Paul Liu.

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Castilla, L., Garrett, L., Adya, N. et al. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia. Nat Genet 23, 144–146 (1999). https://doi.org/10.1038/13776

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