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Unraveling hepatitis B virus infection of mice and men (and woodchucks and ducks)

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Abstract

The development of liver diseases in patients suffering from chronic hepatitis B infection is determined by the nature of the host immune response. Several factors have made this immune response difficult to study, but recently developed animal models will help clear the way.

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Figure 1: Humoral- and cellular-mediated immunity during acute hepatitis B virus (HBV) infection leading to viral clearance.

References

  1. Chang, K-M., & Chisari, F.V. Immuno-pathogenesis of hepatitis B virus infection. Clin. Liver Dis. 3, 221–239 (1999).

    Article  Google Scholar 

  2. Chisari, F.V., & Ferrari, C. In: Viral pathogenesis (ed., Nathanson, N.) 745–778 (Lippincot-Raven, Philadelphia, 1997).

    Google Scholar 

  3. Tennant, B.C. Animal models of hepatitis B virus infection. Clin. Liver Dis. 3, 241–266 (1999).

    Article  Google Scholar 

  4. Vickery, K., Cossart, Y., & Dixon R. Cellular immune response of ducks to duck hepatitis B virus infection. J. Med. Virol. 58, 19–25 (1999).

    Article  CAS  Google Scholar 

  5. Menne, S., Maschke, J., Lu, M., Grosse-Wilde, H., & Roggendorf, M. T-cell response to woodchuck hepatitis virus (WHV) antigens during acute self-limited WHV infection and convalescence and after viral challenge. J. Virol. 72, 6083–6091 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Chisari, F.V. Hepatitis B virus transgenic mice: Models of viral immunobiology and pathogenesis. Curr. Top. Microbiol. 206, 150–173 (1996).

    Google Scholar 

  7. Larkin, J. et al. Hepatitis B virus transgenic SCID mouse model of chronic liver disease. Nature Med. 5, 907–912 (1999).

    Article  CAS  Google Scholar 

  8. Guidotti, L.G. et al. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4, 25–36 (1996).

    Article  CAS  Google Scholar 

  9. Guidotti, L.G. et al. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc. Natl. Acad. Sci. USA. 91, 3764–3768 (1994).

    Article  CAS  Google Scholar 

  10. Guidotti, L.G. et al. Viral clearance without destruction of infected cells during acute HBV infection. Science 284, 25–29 (1999).

    Article  Google Scholar 

  11. Krogsgaard, K. et al. The treatment effect of alpha interferon in chronic hepatitis B is independent of pre-treatment variables. Results based on individual patient data from 10 clinical controlled trials. European Concerted Action on Viral Hepatitis (Eurohep). J. Hepatol. 21, 646–655 (1994).

    Article  CAS  Google Scholar 

  12. Dienstag, J.L. et al. A preliminary trial of lamivudine for chronic hepatitis B infection. N. Engl. J. Med. 333, 1657–1661 (1995).

    Article  CAS  Google Scholar 

  13. Pol, S. et al. Immunotherapy of chronic hepatitis B by anti HBV vaccine. Acta. Gastroenterol. Belg. 61, 228–233 (1998).

    CAS  PubMed  Google Scholar 

  14. Heathcote, J. et al. A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. Hepatology 30, 531–536 (1999).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Sciences, Gastrointestinal Unit, College of Veterinary Medicine, Cornell University, Ithaca, 14853, New York, USA

    Stephan Menne & Bud C. Tennant

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  1. Stephan Menne
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  2. Bud C. Tennant
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Menne, S., Tennant, B. Unraveling hepatitis B virus infection of mice and men (and woodchucks and ducks). Nat Med 5, 1125–1126 (1999). https://doi.org/10.1038/13445

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