Abstract
Determining a 'basis set' of protein folds that represent a majority of protein structures — making use of synchrotron radiation facilities — may be possible in the near future.
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Kerlavage, A.R. TIGR Microbial Genome Database. http://www.tigr.org/tdb/mdb/mdbcomplete.html (1998).
Abola, E.E., Prilusky, J. & Manning, N.O. Protein data bank archivesof three- dimensional macromolecular structures. Meth. Enz. 277, 556– 571 (1997).
Gerstein, M. & Levitt, M.A. Structural census of the current population of protein sequences. Proc. Natl. Acad. Sci. USA 94, 11911–11916 (1997).
Fischer, D. & Eisenberg, D. Assigning folds to the proteins encoded by the genome of Mycoplasma genitalium. Proc. Natl. Acad. Sci. USA 94, 11929–11934 (1997).
Boyd, D., Schierle, C. & Beckwith, J. How many membrane proteins are there? Prot. Sci. 7, 201–205 (1998).
Pascarella, S. & Argos, P. A databank merging related protein structures and sequences. Prot. Engng. 5, 121–137 (1992).
Orengo, C.A., Jones, D.T. & Thornton, J.M. Protein superfamilies and domain superfolds. Nature 372, 631–634 (1994).
Murzin, A., Brenner, S.E., Hubbard, T. & Chothia, C SCOP: A structural classification of proteins for the investigation of sequences and structures. J. Mol. Biol. 247, 536– 540 (1995).
Gibrat, J.F., Madej, T. & Bryant, S.H. Surprising similarities in structure comparison. Curr. Opin. Struct. Biol. 6, 377–385 (1996).
Holm, L. & Sander, C. Mapping the protein universe. Science 273, 595–602 (1996).
Schmidt, R., Gerstein, M. & Altman, R. LPFC: an internet library of protein family core structures. Prot. Sci. 6, 246–248 (1997).
Brenner, S.E., Chothia, C. & Hubbard, T.J. Population statistics of protein structures: lessons from structural classifications. Curr. Opin. Struct. Biol. 7, 369–376 (1997).
Hendrickson, W. and Ogata, C. Phase determination from multiwavelength anomalous diffraction measurements. Meth. Enz. 276,494–523 (1997).
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Kim, SH. Shining a light on structural genomics. Nat Struct Mol Biol 5 (Suppl 8), 643–645 (1998). https://doi.org/10.1038/1334
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DOI: https://doi.org/10.1038/1334
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