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Kinesin: the tail unfolds

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Abstract

The cargo-binding tail of the motor protein kinesin acts as a regulator of kinesin-driven vesicle transport. In the absence of bound cargo, the kinesin tail interacts with the motor domains and inhibits their activity. Cargo binding blocks this interaction and relieves the inhibition.

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Figure 1: Structural predictions for the kinesin tail.
Figure 2: Model for kinesin regulation.

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Authors and Affiliations

  1. the Molecular Motors Group, Marie Curie Research Institute, The Chart, Oxted, Surrey, RH8 0TL, UK

    Robert Cross

  2. the Section of Molecular and Cellular Biology, University of California, Davis, California, 95616, USA

    Jonathan Scholey

Authors
  1. Robert Cross
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  2. Jonathan Scholey
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Correspondence to Jonathan Scholey.

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Cross, R., Scholey, J. Kinesin: the tail unfolds. Nat Cell Biol 1, E119–E121 (1999). https://doi.org/10.1038/12947

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