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The mesh hypothesis of Golgi dynamics

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Abstract

The GTP-binding protein ARF induces the recruitment to the Golgi membrane of kinases that catalyse the synthesis of the lipid phosphatidylinositol-4,5-bisphosphate. This lipid acts as a binding site for certain actin-binding proteins, which may change the Golgi membrane skeleton to a form that allows membrane traffic.

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Figure 1: ARF recruits phosphatidylinositol (PtdIns)-4-OH kinase-β (PI4Kβ) and a PtdIns-4-phosphate-5-OH kinase (PtdIns(4)P-5-OH kinase) to the Golgi membrane1.
Figure 2: The mesh hypothesis of Golgi membrane dynamics.

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Authors and Affiliations

  1. Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, Heidelberg, D-69120, Germany

    Christoph Lorra & Wieland B. Huttner

  2. Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, D-01307, Germany

    Christoph Lorra & Wieland B. Huttner

Authors
  1. Christoph Lorra
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  2. Wieland B. Huttner
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Lorra, C., Huttner, W. The mesh hypothesis of Golgi dynamics. Nat Cell Biol 1, E113–E115 (1999). https://doi.org/10.1038/12939

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