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Nucleotides and cd39: Principal modulatory players in hemostasis and thrombosis

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Abstract

The generation of cd39–/– mice identifies CD39 as a chief vascular ecto-nucleotidase and affirms the importance of purinergic signaling in both hemostasis and thromboregulation (pages 1010–1017).

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Figure 1: a, Role of nucleotides and CD39 in hemostasis.

References

  1. Enjyoji, K. et al. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nature Med. 5, 1010–1017 ( 1999).

    Article  CAS  Google Scholar 

  2. Burnstock, G. Hypoxia, endothelium, and purines. Drug Develop. Res. 28, 301–305 (1993).

    Article  CAS  Google Scholar 

  3. Ralevic, V. in Cardiovascular Biology of Purines (eds. Burnstock,G., Dobson, J.G., Liang, B.T. & Linden, J.) 206–224 (Kluwer Academic Publisher, London, 1998).

    Book  Google Scholar 

  4. Kunapuli, S.P. Multiple P2 receptor subtypes on platelets: a new interpretation of their function. Trends Pharm. Sci. 19, 391– 394 (1998).

    Article  CAS  Google Scholar 

  5. Zimmermann, H. & Pearson, J. in Cardiovascular Biology of Purines (eds. Burnstock, G., Dobson, J.G., Liang, B.T. & Linden, J.) 342–358 (Kluwer Academic Publisher, London, 1998).

    Book  Google Scholar 

  6. Zimmermann, H. Two novel families of ecto-nucleotidases: Molecular structures, catalytic properties, and a search for function. Trends Pharm. Sci. 20, 231–236 (1999).

    Article  CAS  Google Scholar 

  7. Kaczmarek, E. et al. Identification and characterization of CD39 vascular ATP diphosphohydrolase. J. Biol. Chem. 271, 33116– 33122 (1996).

    Article  CAS  Google Scholar 

  8. Marcus, A.J. et al. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J. Clin. Invest. 99, 1351–1360 (1997).

    Article  CAS  Google Scholar 

  9. Gayle, R.B. et al. Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39. J. Clin. Invest. 101, 1851– 1859 (1998).

    Article  CAS  Google Scholar 

  10. Narisawa, S., Fröhlander & N., Millan, J.L. Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Develop. Dynam. 208, 432–446 ( 1997).

    Article  CAS  Google Scholar 

  11. Okawa, A. et al. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nature Genet. 19, 271–273 ( 1998).

    Article  CAS  Google Scholar 

  12. Mulero, J.J., Yeung, G., Nelken, S.T. & Ford, J.E. CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates. J. Biol. Chem. 29, 20064–20067 (1999).

    Article  Google Scholar 

  13. van Son, et al. Decreased expression of glomerular ecto-ATPase in kidney grafts with delayed graft function. Transplant. Proc. 29, 352 –354 (1997).

    Article  CAS  Google Scholar 

  14. Koyamada, N. et al. Apyrase administration prolongs discordant xenograft survival. Transplantation 62, 1739– 1743 (1996).

    Article  CAS  Google Scholar 

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Zimmermann, H. Nucleotides and cd39: Principal modulatory players in hemostasis and thrombosis. Nat Med 5, 987–988 (1999). https://doi.org/10.1038/12419

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