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Human therapeutic cloning

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Abstract

Somatic cell nuclear 'reprogramming' in livestock species is now routine in many laboratories. Here, Robert Lanza, Jose Cibelli and Michael West discuss how these techniques may soon be used to clone genetically matched cells and tissues for transplantation into patients suffering from a wide range of disorders that result from tissue loss or dysfunction.

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Figure 1: Procedure for human therapeutic cloning.

References

  1. Thomson, J.A. et al. Embryonic stem cell lines derived from human blastocytes. Science 282,1145–1147 (1998).

    Article  CAS  Google Scholar 

  2. Shamblott, M.J. et al. Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc. Natl. Acad. Sci. USA 95, 13726–13731 (1998).

    Article  CAS  Google Scholar 

  3. Cibelli, J.B. et al. Transgenic bovine chimeric offspring produced from somatic cell-derived stem-like cells. Nature Biotechnol. 16, 642–646 (1998).

    Article  CAS  Google Scholar 

  4. Langer, R. & Vacanti, J.P. Tissue engineering. Science 260, 920–926 (1993).

    Article  CAS  Google Scholar 

  5. Lanza, R.P. Langer, R. & Chick, W.L. Principles of Tissue Engineering (Academic, San Diego, California, 1997).

    Google Scholar 

  6. Mooney, D.J. & Mikos, A.G. Growing new organs. Sci. Am. 280, 60–65 (1999).

    Article  CAS  Google Scholar 

  7. Wilmut, I., Schnieke, A.E., McWhir, J., Kind, A.J. & Campbell, K.H.S. Viable offspring derived from fetal and adult mammalian cells. Nature 385, 810–813 (1997).

    Article  CAS  Google Scholar 

  8. Campbell, K.H.S., McWhir, J., Ritchie, W.A. & Wilmut, I. Sheep cloned by nuclear transfer from cultured cell line. Nature 380, 64–66 (1996).

    Article  CAS  Google Scholar 

  9. Kato, Y. et al. Eight calves cloned from somatic cells of a single adult. Science 262, 2095–2098 (1998).

    Article  Google Scholar 

  10. Cibelli, J.B. et al. Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science 280, 1256–1258 (1998).

    Article  CAS  Google Scholar 

  11. Baguisi, A. et al. Production of goats by somatic cell nuclear transfer. Nature Biotechnol. 17, 456–461 (1999).

    Article  CAS  Google Scholar 

  12. Robl, J., Cibelli, J. & Stice, S.L. Embryonic or stem-like cell lines produced by cross species nuclear transplantation. International Patent Application Number WO 98/07841. World Intellectual Property Organization, 26 February 1998.

  13. Kenyon, L. & Moraes, C.T. Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids. Proc. Natl. Acad. Sci. USA 94, 9131–9135 (1997).

    Article  CAS  Google Scholar 

  14. Dominko, T. et al. Bovine oocyte cytoplasm supports development of embryos produced by nuclear transfer of somatic cell nuclei from various mammalian species. Biol. Reprod. 60, 1496–1502 (1999).

    Article  CAS  Google Scholar 

  15. Vogel, G. Harnessing the power of stem cells. Science 283, 1432–1434 (1999).

    Article  CAS  Google Scholar 

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Correspondence to Robert P. Lanza.

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Lanza, R., Cibelli, J. & West, M. Human therapeutic cloning. Nat Med 5, 975–977 (1999). https://doi.org/10.1038/12404

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