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AAA-ATPases at the crossroads of protein life and death

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Abstract

The base subcomplex of the yeast 26S proteasome can refold a denatured protein in vitro, a function opposite to its presumed role in protein degradation. Can this paradox be resolved?

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Figure 1: Three-dimensional model of the 26S proteasome23.
Figure 2: The Janus face of AAA-ATPases.

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Authors and Affiliations

  1. the Max-Planck-Institut für Biochemie, Am Klopferspitz 18a, Martinsried, 82152, Germany

    Peter Zwickl & Wolfgang Baumeister

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  1. Peter Zwickl
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  2. Wolfgang Baumeister
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Correspondence to Wolfgang Baumeister.

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Zwickl, P., Baumeister, W. AAA-ATPases at the crossroads of protein life and death. Nat Cell Biol 1, E97–E98 (1999). https://doi.org/10.1038/12097

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