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APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer disease

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Figure 1: Disease-free survival by age for four APOE genotypes.
Figure 2: Disease-free survival by age for groups defined by number of APOE ε4 alleles.

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Acknowledgements

We thank the Neurogenetics Laboratory of the Bryan Alzheimer Disease Research Center at Duke University for determining the APOE genotypes from buccal material. J. Anthony and R. Brookmeyer provided helpful discussions on methods. We thank G. Einstein for her helpful critique of the manuscript.

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Authors and Affiliations

  1. Department of Mental Hygiene, The Johns Hopkins University, 624 North Broadway, Baltimore, 21205, Maryland, USA

    Marion R Meyer & John C S Breitner

  2. College of Family Life, Utah State University, Logan, Utah, USA

    JoAnn T Tschanz, Maria C Norton & Bonita W Wyse

  3. Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA

    Kathleen A Welsh-Bohmer, David C Steffens & John C S Breitner

  4. The Joseph and Kathleen Bryan Alzheimers Disease Research Center, Duke University, Durham, North Carolina, USA

    Kathleen A Welsh-Bohmer & John C S Breitner

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  1. Marion R Meyer
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  2. JoAnn T Tschanz
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  3. Maria C Norton
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  4. Kathleen A Welsh-Bohmer
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  5. David C Steffens
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  6. Bonita W Wyse
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  7. John C S Breitner
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Meyer, M., Tschanz, J., Norton, M. et al. APOE genotype predicts when — not whether — one is predisposed to develop Alzheimer disease. Nat Genet 19, 321–322 (1998). https://doi.org/10.1038/1206

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