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Apoptosis: the germs of death

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Abstract

From the initial recognition that programmed cell suicide existed, to the elucidation of the underlying death and survival pathways at the molecular level, the story of apoptosis has unfolded rapidly. But much still remains to be discovered.

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Figure 1: Apoptosis in development.
Figure 2: Hallmarks of classical apoptosis.

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References

  1. Weissmann, A. Essays upon Hereditary and Kindred Biological Problems (eds Poulton, E. B., Schonland S. & Shipley, A. E.) 25 (Oxford Press, Oxford, 1889).

    Google Scholar 

  2. Gräper, L. Arch. Zellforsch. 12, 373–394 (1914).

    Google Scholar 

  3. Glücksmann, A. Biol. Rev. Camb. Phil. Soc. 26, 59–86 (1951).

    Article  Google Scholar 

  4. Saunders, J. W. Jr Science 154, 604–612 (1966).

    Article  Google Scholar 

  5. Lockshin, R. A. & Beaulaton, J. Life Sci. 15, 1549–1565 (1974).

    Article  CAS  Google Scholar 

  6. Oppenheim, R. W. Neuron 17, 195–197 (1996).

    Article  CAS  Google Scholar 

  7. Kerr, J. F. J. Pathol. 105, 13–20 (1971).

    Article  CAS  Google Scholar 

  8. Bellairs, R. J. Anat. 95, 54–60 (1961).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Kerr, J., Wyllie, A. & Currie, A. Br. J. Cancer 26, 239–257 (1972).

    Article  CAS  Google Scholar 

  10. Hengartner, M. O. Curr. Opin. Genet. Dev. 6, 34–38 (1996).

    Article  CAS  Google Scholar 

  11. Bergmann, A., Agapite, J. & Steller, H. Oncogene 17, 3215–3223 (1998).

    Article  Google Scholar 

  12. Trauth, B. C. et al. Science 245, 301–305 (1989).

    Article  CAS  Google Scholar 

  13. Yonehara, S., Ishii, A. & Yonehara, M. J. Exp. Med. 169, 1747–1756 (1989).

    Article  CAS  Google Scholar 

  14. Itoh, N. et al. Cell 66, 233–243 (1991).

    Article  CAS  Google Scholar 

  15. Vaux, D. L., Cory, S. & Adams, J. M. Nature 335, 440–442 (1988).

    Article  CAS  Google Scholar 

  16. Frisch, S. M. & Ruoslahti, E. Curr. Opin. Cell. Biol. 9, 701–706 (1997).

    Article  CAS  Google Scholar 

  17. Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H. & Ley, T. J. Cell 76, 977–987 (1994).

    Article  CAS  Google Scholar 

  18. Greenberg, A. H. Adv. Exp. Med. Biol. 406, 219–228 (1996).

    Article  CAS  Google Scholar 

  19. American Association for Cancer Research Special Conference in Cancer Research Cell Death and Cancer (Cape Cod, Massachusetts, 1993).

  20. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. & Horvitz, H. Cell 75, 641–652 (1993).

    Article  CAS  Google Scholar 

  21. Zou, H., Henzel, W. J., Liu, X., Lutschg, A. & Wang, X. Cell 90, 405–413 (1997).

    Article  CAS  Google Scholar 

  22. Kroemer, G. Nature Med. 3, 614–620 (1997).

    Article  CAS  Google Scholar 

  23. Muzio, M. et al. Cell 85, 817–827 (1996).

    Article  CAS  Google Scholar 

  24. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V. & Wallach, D. Cell 85, 803–815 (1996).

    Article  CAS  Google Scholar 

  25. Adams, J. M. & Cory, S. Science 281, 1322–1326 (1998).

    Article  CAS  Google Scholar 

  26. Susin, S. et al. J. Exp. Med. 184, 1331–1341 (1996).

    Article  CAS  Google Scholar 

  27. Yonish-Rouach, E. et al. Nature 352, 345–347 (1991).

    Article  CAS  Google Scholar 

  28. Evan, G. & Littlewood, T. Science 281, 1317–1322 (1998).

    Article  CAS  Google Scholar 

  29. White, E. Genes Dev. 10, 1–15 (1996).

    Article  CAS  Google Scholar 

  30. Flemming, W. Arch. Anat. EntwGesch. 221–244 (1885).

  31. Majno, G. & Joris, I. Am. J. Pathol. 146, 3–15 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Wyllie, A. H. Cancer Metastasis Rev. 11, 95–103 (1992).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK

    Tina Rich, Christine J. Watson & Andrew Wyllie

Authors
  1. Tina Rich
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  2. Christine J. Watson
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  3. Andrew Wyllie
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Correspondence to Andrew Wyllie.

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Rich, T., Watson, C. & Wyllie, A. Apoptosis: the germs of death. Nat Cell Biol 1, E69–E71 (1999). https://doi.org/10.1038/11038

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