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Caspases land on APP: One small step for apoptosis, one giant leap for amyloidosis?

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Abstract

Gervais et al. suggest that caspase cleavage of amyloid precursor protein (APP) may initiate a feedback loop that produces β-amyloid deposits in Alzheimer's disease.

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Figure 1: A model for the relationship between caspase activation, caspase cleavage of APP and the generation of Aβ, including the role of presenilin FAD mutations.

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Authors and Affiliations

  1. Department of Neurology, Harvard Medical School, Massachusetts General Hospital, 149 13 th Street, Charleston, 02129, Massachusetts, USA

    Rudolph E. Tanzi

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  1. Rudolph E. Tanzi
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Tanzi, R. Caspases land on APP: One small step for apoptosis, one giant leap for amyloidosis?. Nat Neurosci 2, 585–586 (1999). https://doi.org/10.1038/10133

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