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Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxides

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Abstract

The ability of ultrafine particles of TiO2, WO3 and iron-doped TiO2 to kill cancer cells in the presence of UV irradiation was investigated. The best photokilling effect on carcinoma cells SCVII cultured in vitro showed iron-doped TiO2 ultrafine particles synthesized by the sol-gel procedure with starting chemicals Ti(IV)-isopropoxide and anhydrous Fe(II)-acetate. It was found that a small particle size and high dispersity influenced citotoxicity and photocatalytic efficiency. The remarkable photokiling effect of highly iron-doped TiO2 ultrafine particles (the molar ratio Fe/Ti = 0.136) in the presence of UV irradiation was observed. The influence of ultrafine metal oxide particles on the inhibition of cancer cell proliferation was measured using a 3H-thymidine incorporation test. The possible mechanism involved in the photokilling of carcinoma cells with ultrafine particles of selected metal oxides was discussed.

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Authors
  1. Siniša Ivanković
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  2. Marijan Gotić
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  3. Mislav Jurin
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  4. Svetozar Musić
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Ivanković, S., Gotić, M., Jurin, M. et al. Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxides. Journal of Sol-Gel Science and Technology 27, 225–233 (2003). https://doi.org/10.1023/A:1023715004575

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