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Isolation and Characterization of Full and Truncated Forms of Human Breast Carcinoma Protein BA46 from Human Milk Fat Globule Membranes

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Abstract

We have isolated and characterized two proteins of 50 and 30 kDa from human milk fat globule membranes of healthy donors. N-terminal and internal sequencing revealed that the 50-kDa protein is the full-length human breast carcinoma protein BA46 that is highly expressed in human breast tumors. The 30-kDa protein is a truncated form of protein BA46 which consists of the C-terminal factor V/VIII-like domain of BA46 and which appears to anchor BA46 to the milk fat globule membrane. Defective release of the epidermal growth factor domain containing a surface RGD motif may be related to involvement of BA46 in breast cancer

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Authors and Affiliations

  1. Institut für Molekulare Biotechnologie, Jena, Germany

    Maria Gabriella Giuffrida & Jasminka Godovac-Zimmermann

  2. Centre Studio Alimentazione Animali, Torino, Italy

    Maria Gabriella Giuffrida & Amedeo Conti

  3. Dipartimento di Biologia Animale, Università di Torino, Italy

    Maria Cavaletto & Carlo Giunta

Authors
  1. Maria Gabriella Giuffrida
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  2. Maria Cavaletto
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  3. Carlo Giunta
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  4. Amedeo Conti
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  5. Jasminka Godovac-Zimmermann
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Correspondence to Jasminka Godovac-Zimmermann.

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Giuffrida, M.G., Cavaletto, M., Giunta, C. et al. Isolation and Characterization of Full and Truncated Forms of Human Breast Carcinoma Protein BA46 from Human Milk Fat Globule Membranes. J Protein Chem 17, 143–148 (1998). https://doi.org/10.1023/A:1022531500370

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  • DOI: https://doi.org/10.1023/A:1022531500370

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