Neurochemical Research

, Volume 28, Issue 1, pp 73–82

Association of Seven Polymorphisms of the D2 Dopamine Receptor Gene with Brain Receptor-Binding Characteristics

Article

DOI: 10.1023/A:1021648128758

Cite this article as:
Ritchie, T. & Noble, E.P. Neurochem Res (2003) 28: 73. doi:10.1023/A:1021648128758

Abstract

Association of alleles at the Taql A, Taql B, intron 6, Taql D, exon 7, exon 8, and promoter-141C sites of the D2 dopamine receptor gene with D2 dopamine receptor binding characteristics in the caudate nucleus of Caucasian alcoholic and nonalcoholic subjects was determined. For the Taql D, exon 7, exon 8, and promoter-141C sites there were no significant allelic differences in Bmax (number of binding sites) or Kd (binding affinity) of the D2 dopamine receptors. However, subjects having the minor alleles at the Taql A, Taql B, and intron 6 sites had significantly lower Bmax than subjects not having them. None of these three polymorphisms had any significant effect on Kd. Highly significant linkage disequilibria were observed among the Taql A, Taql B, and intron 6 polymorphic sites, but linkage disequilibria between these three sites and each of the Taql D, exon 7, exon 8, and promoter-141C sites were of lesser or of no significance. Taken together, these findings suggest that the Taql A, Taql B, and intron 6 polymorphisms, but not the Taql D, exon 7, exon 8, and promoter-141C polymorphisms, are in linkage disequilibrium with a functional allelic variant that affects D2 dopamine receptor expression.

D2 dopamine receptor geneD2 dopamine receptor bindingpolymorphismalcoholismlinkage disequilibriumallelic association

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  1. 1.Department of Psychiatry and Biobehavioral SciencesUniversity of CaliforniaLos Angeles