Abstract
Amentoflavone, a biflavonoid with antiinflammatory activity, downregulates COX-2 expression in TNFα-activated A549 cells with concomitant inhibition of NF-κB mediated signaling cascades. We demonstrate here that amentoflavone inhibits NF-κB/DNA binding activity potently along with inhibition of degradation of IκBα and NF-κB translocation into nucleus in TNFα-activated A549 cells. This flavonoid upregulates PPAR γ, a transcription factor involved in repressing many cytokine-induced gene expressions. Hence amentoflavone, a dietary constituent, may be of therapeutic value for several lung diseases where COX-2 plays an important role.
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Banerjee, T., Valacchi, G., Ziboh, V.A. et al. Inhibition of TNFα-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-κB activation in A549 cells. Mol Cell Biochem 238, 105–110 (2002). https://doi.org/10.1023/A:1019963222510
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DOI: https://doi.org/10.1023/A:1019963222510