Evolutionary biology and the concept of disease
- Anne Gammelgaard
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In recent years, an increasing number of medical books and papers attempting to analyse the concepts of health and disease from the perspective of evolutionary biology have been published (Eaton etal., 1993; Ewald, 1993; Harrison, 1993; Nesse and Williams, 1995; Profet, 1991; Rose, 1991; Temple and Burkitt, 1994).
This paper introduces the evolutionary approach to health and disease in an attempt to illuminate the premisses and the framework of Darwinian medicine. My primary aim is to analyse to what extent evolutionary theory provides for a biological definition of the concept of disease. This analysis reveals some important differences between functional explanations in the field of evolutionary biology and functional explanations in the field of medicine. Moreover, I shall argue that the biological functions relevant to the health of an organism cannot be determined on the basis of evolutionary theory. Accordingly, it seems that Darwinian medicine does not provide for the definition of a biological concept of disease. Still,Darwinian medicine may suggest why we are susceptible to certain diseases; it might also prove a suggestive heuristic on the basis of which new hypotheses concerning relevant treatments of various diseases might be advanced.
- Allen, C., M. Bekoff and G. Lauder (eds.): 1998, Nature's Purposes: Analysis of Function and Design in Biology. Cambridge, MA: M.I.T. Press.
- Boorse, C.: 1975, 'On the distinction between disease and illness', Philosophy and Public Affairs 5, pp. 49-68.
- Boorse, C.: 1976a, 'Wright on functions', Philos. Rev. 85, pp. 70-86. CrossRef
- Boorse, C.: 1976b, 'What a theory of mental health should be', J.Theory of Social Behaviour 6, pp. 61-84.
- Boorse, C.: 1977, 'Health as a theoretical concept', Philos. Sci. 44, pp. 542-573. CrossRef
- Boorse, C.: 1997, 'A Rebuttal on Health', in J.M. Humber and R.F. Almeder (eds.), What is Disease? Totowa: Humana Press.
- Brandon, R.N. and R.M. Burian (eds.): 1984, Genes, Organisms, Populations: Controversies over the Units of Selection. Cambridge, MA: M.I.T. Press.
- Brown, W.M.: 1985, 'On defining disease', J. Med. Phil. 10, pp. 311-328.
- Cavalier-Smith, T.: 1980, 'How selfish is DNA?', Nature 285, pp. 617-618. CrossRef
- Cummins, R.: 1975, 'Functional analysis', J. Philos. 72, pp. 741-764. CrossRef
- Dawkins, R.: 1976, The Selfish Gene. Oxford: Oxford University Press.
- Eaton, S.B., M.C. Pike, R.V. Short, N.C. Lee, J. Trussel and R.A. Hatcher et al.: 1993, 'Women's reproductive cancers in evolutionary context', The Quarterly Review of Biology 69, pp. 353-367.
- Engelhardt, H.T. Jr.: 1986, The Foundations of Bioethics. New York, Oxford: Oxford University Press.
- Ewald, P.W.: 1993, Evolution of Infectious Disease. Oxford: Oxford University Press.
- Gordeuk, V.R., P.E. Thuma, G.M. Brittenham, S. Zulu, G. Simwanza and A. Mhangu et al.: 1992a, 'Iron chelation with desferrioxamine B in adults with asymptotic Plasmodium falciparum parasitemia', Blood 79, pp. 308-312.
- Gordeuk, V.R., P.E. Thuma, G.M. Brittenham, C. McLaren, D. Parry and A. Backenstose et al.: 1992b, 'Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria', N. Eng. Jour. Med. 327, pp. 1473-1477. CrossRef
- Harrison, G.A.S. (ed.): 1993, Human Adaptation. Oxford: Oxford University Press.
- Kovács, J.: 1998, 'The concept of health and disease', Medicine, Health Care and Philosophy 1, pp. 31-39. CrossRef
- Margolis, J.: 1976, 'The concept of disease', J. Med. Philos. 1, pp. 238-255.
- Miller, J.F., J.J. Mekalanos and S. Falkow: 1989, 'Coordinate regulation and sensory transduction in the control of bacterial virulence', Science 243, pp. 916-922.
- Millikan, R.G.: 1989, 'In defense of proper functions', Philos. Sci. 56, pp. 288-302. CrossRef
- Nesse, R.M. and G.C. Williams: 1995, Evolution and Healing: The New Science of Darwinian Medicine. London: Phoenix.
- Orgel, L.E., F.H.C. Crick and C. Sapienza: 1980, 'Selfish DNA', Nature 288, pp. 645-646. CrossRef
- Preston, B.: 1998, 'Why is a wing like a spoon? A pluralist theory of function', The Journal of Philosophy XCV(5), pp. 215-254. CrossRef
- Profet, M.: 1991, 'The Function of Allergy: Immunological defense against toxins', The Quarterly Review of Biology 6, pp. 23-62.
- Reznek, L.: 1987, The Nature of Disease. London: Routledge and Kegan Paul.
- Reznik, D.: 1997, 'Adaptationism: hypothesis or heuristic?', Biology and Philosophy 12, pp. 39-50. CrossRef
- Rose, M.R.: 1991, Evolutionary Biology of Aging. Oxford: Oxford University Press.
- Rottschaefer, W.A.: 1997, 'Adaptational functional ascriptions in evolutionary biology: a critique of Schaffner's views', Philos. Sci. 64, pp. 698-713. CrossRef
- Schaffner, K.F.: 1993, Discovery and Explanation in Biology and Medicine. Chicago: The University of Chicago Press.
- Sober, E.: 1991, 'Organisms, individuals, and the units of selection', in A. Tauber (ed.), Organism and the Origins of Self. Dordrecht: Kluwer Academic Publishers, pp. 275-296.
- Sober, E.: 1993, Philosophy of Biology. Oxford: Oxford University Press.
- Sober, E. and D.S. Wilson: 1994, 'A critical review of philosophical work on the unit of selection problem', Philos. Sci. 61, pp. 534-555.
- Stove, D.: 1995, Darwinian Fairytales. Aldershot: Avebury.
- Temple, N.J. and D.P. Burkitt (eds.): 1994, Western Diseases: Their Prevention and Reversibility. New Jersey: Humana Press.
- Wimsatt, W.: 1972, 'Teleology and the logical structure of function statements', Stud. Hist. Philos. Sci. 3, pp. 1-80. CrossRef
- Wright, L.: 1973, 'Functions', Philos. Rev. 82, pp. 139-168. CrossRef
- Evolutionary biology and the concept of disease
Medicine, Health Care and Philosophy
Volume 3, Issue 2 , pp 109-116
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
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- concept of disease
- Darwinian medicine
- evolutionary biology
- functional explanations
- Industry Sectors
- Anne Gammelgaard (1)
- Author Affiliations
- 1. Department of Medical Philosophy and Clinical Theory, Institute of Public Health, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen