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Somatostatin analogs: angiogenesis inhibitors with novel mechanisms of action

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References

  1. Krulich L, Dhariwal A, McCann S: Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro. Endocrinology 83:783, 1968

    Google Scholar 

  2. Brazeau P, Somatostatin: A peptide with unexpected physiologic activities. Am J Med 71(Suppl. 61B):8–13, 1986

    Google Scholar 

  3. Mozell E, Stenzel P, Woltering EA, Rosch J, O'Dorisio TM: Functional Endocrine Tumors of the Pancreas: Clinical Presentation, Diagnosis, and Treatment. St. Louis, MO: Mosby Year Book, 1990

    Google Scholar 

  4. Pollak MN, Polychronakos C, Yousefi S, Richard M: Characterization of insulin-like growth factor I (IGF-I) receptors of human breast cancer cells. Biochem Biophys Res Commun 154(1):326–331, 1988

    Google Scholar 

  5. Pollak M, Costantino J, Polychronakos C, Blauer SA, Guyda H, Redmond C, Fisher B, Margolese R: Effect of tamoxifen on serum insulinlike growth factor I levels in stage I breast cancer patients. JNCI 82(21):1693–1697, 1990

    Google Scholar 

  6. Williams ST, Woltering EA, O'Dorisio TM, Fletcher WS: Effect of octreotide acetate on pancreatic exocrine function. Am J Surg 157:459–462, 1989

    Google Scholar 

  7. Ellison EC, O'Dorisio TM, Woltering EA, Sparks J, Mekhjian HS, Fromkes JJ, Carey LC: Suppression of gastrin and gastric acid secretion in the Zollinger-Ellison Syndrome by long-acting somatostatin (SMS 201–995). Scand J Gastroenterol 21(Suppl. 119):170–176, 1986

    Google Scholar 

  8. Richards WO, Geer R, O'Dorisio TM, Robarts T, Parish KL, Rice D, Woltering G, Abumrad NN: Octreotide acetate induces fasting small bowel motility in patients with dumping syndrome. J Surg Res 49:483–487, 1990

    Google Scholar 

  9. O'Dorisio MS, Chen F, O'Dorisio TM, Wray D, Qualman SJ: Characterization of somatostatin receptors on human neuroblastoma tumors. Cell Growth and Differentiation 5:1–8, 1994

    Google Scholar 

  10. Mozell EJ, Woltering EA, O'Dorisio TM: Non-endocrine applications of somatostatin and octreotide acetate: facts and flights of fancy. Disease-a-Month 37(12):751–848, 1991

    Google Scholar 

  11. Raynor K, Murphy WA, Coy DH, Taylor JE, Moreau J-P, Yasuda K, Bell GI, Reisine T: Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Molecular Pharmacology 43:838–844, 1993

    Google Scholar 

  12. Raynor K, O'Carroll AM, Kong H, Yasuda K, Mahan LC, Bell GI, Reisine T: Characterization of cloned somatostatin receptors SSTR4 and SSTR5. Molecular Pharmacology 44(2):385–392, 1993

    Google Scholar 

  13. Krenning EP, Kwekkeboom DJ, Bakker WH, Breeman WAP, Kooij PPM, Oei HY, van Hagen M, Postema PTE, de Jong M, Reubi JC, Visser TJ, Reijs AEM, Hofland LJ, Koper JW, Lamberts SWJ: Somatostatin receptor scintigraphy with (111ln-DTPA-D-Phe1) and (123l-tyr3)-octreotide: the Rotterdam experience with more than 1,000 patients. Eur J Nucl Med 20:716–731, 1993

    Google Scholar 

  14. Scheidhauer K, Hildebrand G, Luyken C, Schomacker S, Klug N, Schicha H: Somatostatin receptor scintigraphy in brain tumors and pituitary tumors: first experiences. Horm Metab res 27(Suppl.):59–62, 1993

    Google Scholar 

  15. Hoefnagel CA, Rankin EM, Validesolmos RA, Israelis SP, Pavel S, Janssen AGM: Sensitivity versus specificity in melanoma imaging using iodine-123 iodobenzamid and indium-111-pentetreotide. Eur J Nucl Med 21:587–588, 1994

    Google Scholar 

  16. Woltering EA, O'Dorisio MS, O'Dorisio TM: The role of radiolabeled somatostatin analogs in the management of cancer patients. PPO Updates 9(8):1–16, 1995

    Google Scholar 

  17. Sharma C, Alperin-Lea RC, Johnson MA, Burleigh BD, Woltering EA: Inhibition of octreotide acetate (OA) on proliferation of porcine coronary artery smooth muscle, endothelium, and fibroblasts cells. FASEB 9(3):(Abstract), 1995

  18. Anthony L, Johnson D, Hande K, Shaff M, Winn S, Krozely M, Oates J: Somatostatin analog Phase I trial in neuroendocrine neoplasms. Acta Oncol 32(2):217–223, 1993

    Google Scholar 

  19. Mozell E, Woltering EA, O'Dorisio TM, Fletcher WS, Sinclair AJ, Hill D: Effect of somatostatin analog on peptide release and tumor growth in the Zollinger-Ellison Syndrome. SG&O 170(6):476–484, 1990

    Google Scholar 

  20. Patel PC, Barrie R, Hill N, Landeck S, Kurozawa D, Woltering EA: Post-receptor signal transduction mechanisms involved in octreotide-induced inhibition of angiogenesis. Surg 116(6):1148–1152, 1994

    Google Scholar 

  21. Barrie R, Woltering EA, Hajarizaheh H, Mueller C, Ure T, Fletcher WS: Inhibition of angiogenesis by somatostatin and somatostatin-like compounds is structurally dependent. J Surg Res 55:446–450, 1993

    Google Scholar 

  22. Woltering EA, Barrie R, O'Dorisio TM, Arce D, Ure T, Cramer A, Holmes D, Robertson J, Fassler J: Somatostatin analogues inhibit angiogenesis in the chick chorioallantoic membrane. J Surg Res 50:245–251, 1991

    Google Scholar 

  23. Bloom SR, Mortimer CM, Thorner MO et al.: Inhibition of gastrin and gastric acid secretion by growth-hormone release-inhibiting hormone. Lancet 2:1106–1109, 1974

    Google Scholar 

  24. Heisler S, Reisine TD, Hook VYH, Axelrod J: Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells. Proc Natl Acad Sci 79:6502–6506, 1982

    Google Scholar 

  25. French MB, Moor BC, Lussier BT, Kraicer J: Protein kinase-C is not essential for growth hormone (GH)-releasing factor-induced GH release from rat somatotrophs. Endocrinology 124:2235–2244, 1989

    Google Scholar 

  26. Reisine T: Multiple mechanisms of somatostatin inhibition of adrenocorticotropin release from mouse anterior pituitary cells. Endocrinology 116:2259–2266, 1985

    Google Scholar 

  27. Woltering EA: 1995 (UnPub)

  28. Maynes S, Bezos A, Parish C: A novel in vitro assay for human angiogenesis. New Cancer Strategies: Angiogenesis Antagonists (Abstract), 1995

    Google Scholar 

  29. Weber C, Merriam L, Koschitzky T, Karp F, Benson M, Forde K, LoGerfo P: Inhibition of growth of human breast carcinomas in vivo by somatostatin analog SMS 201–995: treatment of nude mouse xenografts. Surg 106:416–422, 1989

    Google Scholar 

  30. Weckbecker G, Tolcsvai L, Stolz B, Pollak M, Bruns C: Somatostatin analog octreotide enhances the antineoplastic effects of tamoxifen and ovarietomy on 7,12-dimethylben-z(a)anthracene-induced rat mammary carcinomas. Cancer Res 54(24):6334–6337, 1995

    Google Scholar 

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Woltering, E.A., Watson, J.C., Alperin-Lea, R.C. et al. Somatostatin analogs: angiogenesis inhibitors with novel mechanisms of action. Invest New Drugs 15, 77–86 (1997). https://doi.org/10.1023/A:1005774713202

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