Abstract
The effectiveness of therapeutically used iron compounds is related to their physical and chemical properties. Four different iron compounds used in oral, intravenous, and intramuscular therapy have been examined by X-ray powder diffraction, iron-57 Mössbauer spectroscopy, transmission electron microscopy, BET surface area measurement, potentiometric titration and studied through dissolution kinetics determinations using acid, reducing and chelating agents. All compounds are nanosized with particle diameters, as determined by X-ray diffraction, ranging from 1 to 4.1 nm. The superparamagnetic blocking temperatures, as determined by Mössbauer spectroscopy, indicate that the relative diameters of the aggregates range from 2.5 to 4.1 nm. Three of the iron compounds have an akaganeite-like structure, whereas one has a ferrihydrite-like structure. As powders the particles form large and dense aggregates which have a very low surface area on the order of 1 m2 g−1. There is evidence, however, that in a colloidal solution the surface area is increased by two to three orders of magnitude, presumably as a result of the break up of the aggregates. Iron release kinetics by acid, chelating and reducing agents reflect the high surface area, the size and crystallinity of the particles, and the presence of the protective carbohydrate layer coating the iron compound. Within a physiologically relevant time period, the iron release produced by acid or large chelating ligands is small. In contrast, iron is rapidly mobilized by small organic chelating agents, such as oxalate, or by chelate-forming reductants, such as thioglycolate.
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References
Danielson, B. G., Geisser, P. and Schneider, W., Iron Therapy, Vifor (International) Inc., St. Gallen, 1996.
Schneider, W., Chimia 42 (1988), 9.
Crichton, R. R., Inorganic Biochemistry of Iron Metabolism, Ellis Horwood Limited, Chichester, 1991.
Rietveld, H., J. Appl. Cryst. 2 (1969), 65.
Young, R., The Rietveld Method, International Union of Cristallography, 1993.
Williamson, G. and Hall, W., Acta Metallurgicae 1 (1953), 22.
Le Caër, G. and Dubois, J. M., J. Phys. E. Sci. Instrum. 12 (1979), 1083.
Wivel, C. and Mørup, S., J. Phys. E. Sci. Instrum. 14 (1981), 605.
Weidler, P. G., J. Porous Mat. 4 (1997), 165.
Brunauer, S., Emmett, P. H. and Teller, E., J. Am. Chem. Soc. 60 (1932), 309.
Kinniburgh, D. G., Milne, C. J. and Venema, P., Soil Sci. Soc. Am. J. 59 (1995), 417.
Baes, C. F. and Mesmer, R. E., The Hydrolysis of Cations, Wiley, New York, 1976.
McKay, A. L., Mineralogical Magazine 32 (1960), 545.
Szytula, A., Burewicz, A. and Dimitrijevic, Z., Phys. Stat. Sol. A 3 (1970), 1033.
Cornell, R. M. and Schwertmann, U., The Iron Oxides, VCH Verlagsgesellschaft mbH, Weinheim, 1996.
Weidler, P. G., Oberflächen und Porositäten synthetischer Eisenoxide, PhD thesis, Dissertationsverlag NG Kopierladen GmbH, Muenchen, 1995.
Drits, V., Sakharov, B., Salyn, A. and Manceau, A., Clay Min. 28 (1993), 185.
Chambaere, D., Govaert, A., de Sitter, J. and de Grave, E., Solid State Commun. 26 (1978), 657.
Childs, C., Goodman, B., Paterson, E. and Woodhams, F., Aust. J. Chem. 33 (1980), 15.
Chambaere, D. G. and de Grave, E., J. Magn. Magn. Mater. 42 (1984), 263.
Chambaere, D. G. and de Grave, E., J. Magn. Magn. Mater. 42 (1984), 349.
Mørup, S., Madsen, M. B., Franck, J., Villadsen, J. and Koch, C. J. W., J. Magn. Magn. Mater. 40 (1983), 163.
Mørup, S., In: Mössbauer Spectroscopy Applied to Inorganic Chemistry, Vol. 2, G. J. Long (ed.), Plenum Press, New York, 1987, p. 89.
Quinn, T. G., Long, G. J., Benson, C. G., Mann, S. and Williams, R. J. P., Clay Clay Min. 26 (1988), 165.
Tronc, E., Il Nuovo Cimento 18 (1996), 163.
Néel, L., Ann. Geophys. 5 (1949), 99.
Kanungo, S. B., J. Colloid Interface Sci. 162 (1994), 86.
Sidhu, P. S., Gilkes, R. J., Cornell, R. M., Posner, A. M. and Quirk, J. P., Clay Clay Min. 29 (1981), 269.
Rubio, J. and Matijevic, E., J. Colloid Interface Sci. 68 (1979), 408.
Smith, R. M. and Martell, A. E., Critical Stability Constants, Vol. 6, 2nd Supplement, Plenum Press, New York, 1989.
Schwertmann, U., Z. Pflanzenern. Düng. Bodenkd. 105 (1964), 194.
Geisser, P., Baer, M. and Schaub, E., Arzneim.-Forsch./Drug Res. 42 (1992), 1439.
Zinder, B., Furrer, G. and Stumm, W., Geochim. Cosmochim. Acta 50 (1986), 1861.
Leussing, D. L. and Kolthoff, I. M., J. Am. Chem. Soc. 75 (1953), 3904.
Funk, F., Lenders, J.-P., Crichton, R. R. and Schneider, W., Eur. J. Biochem. 152 (1985), 167.
Baumgartner, E., Blesa, M. A. and Maroto, A. J. G., J. Chem. Soc. Dalton Trans. (1982), 1649.
Amirbahman, A., Sigg, L. and von Gunten, U., J. Colloid Interface Sci. 194 (1997), 194.
Danielson, B. G., Salmonson, T., Derendorf, H. and Geisser, P., Arzneim.-Forsch./Drug Res. 46 (1996), 615.
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Funk, F., Long, G.J., Hautot, D. et al. Physical and Chemical Characterization of Therapeutic Iron Containing Materials: A Study of Several Superparamagnetic Drug Formulations with the β-FeOOH or Ferrihydrite Structure. Hyperfine Interactions 136, 73–95 (2001). https://doi.org/10.1023/A:1015552311359
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DOI: https://doi.org/10.1023/A:1015552311359