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Chiral synthesis of alpha-phenylpyridylmethanols with Rhizopus arrhizus

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Abstract

The bioreduction of 2-benzoylpyridine (1a) with Rhizopus arrhizus afforded (S)-(+)-alpha-phenyl-2-pyridylmethanol (2a) in 82% enantiomeric excess (e.e.) while the asymmetric hydrolysis of its racemic acetate resulted in the antipode (R)-(-)-2a with 24% optical purity.

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Authors and Affiliations

  1. Bio-Organic Division, Bhabha Atomic Research Centre, Microbial Chemistry Section, Mumbai, India

    Neeta A. Salvi, Sanninje R. Udupa & Asoke Banerji

Authors
  1. Neeta A. Salvi
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  2. Sanninje R. Udupa
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  3. Asoke Banerji
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Salvi, N.A., Udupa, S.R. & Banerji, A. Chiral synthesis of alpha-phenylpyridylmethanols with Rhizopus arrhizus. Biotechnology Letters 20, 201–203 (1998). https://doi.org/10.1023/A:1005301229609

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  • DOI: https://doi.org/10.1023/A:1005301229609

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