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The involvement of galectin-1 in skeletal muscle determination, differentiation and regeneration

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Abstract

The dogma that a cell is rigidly committed to one tissue type has been heavily challenged over the past few years with numerous reports of transdifferentiation of cells between different lineages. Cells capable of entering lineages other than that of their tissue of origin have been identified in several diverse tissues. Recently we have focussed on a non-committed myogenic cell within the dermis that is capable, under certain conditions, of expressing muscle specific markers and even fusing to the terminally differentiated stage of muscle cell development. We have identified galectin-1 as being a potent factor implicated in this process. In this review we discuss our findings and consider the involvement of galectin-1 in muscle determination, differentiation and regeneration. Published in 2004.

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Authors and Affiliations

  1. Department of Anatomy, Brighton and Sussex Medical School, Medical School Building, Falmer, Brighton, East Sussex, BN1 9PX, UK

    Diana J. Watt

  2. Randall Centre for Molecular Mechanisms of Cell Function, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK

    Gareth E. Jones

  3. UK Parkinson's Disease Society Tissue Bank at Imperial College, Division of Neuroscience & Psychological Medicine, Imperial College Faculty of Medicine, Charing Cross Campus, St Dunstan's Road, London, W6 8RP, UK

    Kirstin Goldring

Authors
  1. Diana J. Watt
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  2. Gareth E. Jones
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  3. Kirstin Goldring
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Correspondence to Diana J. Watt.

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Watt, D.J., Jones, G.E. & Goldring, K. The involvement of galectin-1 in skeletal muscle determination, differentiation and regeneration. Glycoconj J 19, 615–619 (2002). https://doi.org/10.1023/B:GLYC.0000014093.23509.92

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  • DOI: https://doi.org/10.1023/B:GLYC.0000014093.23509.92

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