Skip to main content
Log in

Role of Aqueous Medium in Mechanisms Underlying the Influence of Immunoactive Peptides in Ultralow Doses

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The mechanism underlying the influence of peptides in ultralow doses is based on distant signal transduction from the ligand molecules to target cells by means of water solitons. Biological activity of synthetic immunoactive peptides in concentrations below 10-18 M depends on their structural and conformational characteristics. The data on temperature dependencies of the near-infrared spectrum for solutions of these peptides are presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. L. A. Blyumenfel'd, Biofizika, 38, No. 1, 129-132 (1993).

    Google Scholar 

  2. E. B. Burlakova, Vestn. Ros. Akad. Nauk, 64, No. 5, 425-431 (1994).

    Google Scholar 

  3. E. B. Burlakova, Ros. Khim. Zh., 43, No. 5, 3-11 (1999).

    Google Scholar 

  4. S. D. Varfolomeev and S. V. Zaitsev, Kinetic Methods in Biochemical Assays [in Russian], Moscow (1982).

  5. E. I. Grigor'ev, V. Kh. Khavinson, I. N. Kochnev, et al., Byull. Eksp. Biol. Med., 133, No. 5, 525-529 (2002).

    Google Scholar 

  6. I. N. Kochnev, A. I. Khaloimov, E. I. Grigor'ev, et al., Biofizika, 47, No. 1, 12-19 (2002).

    Google Scholar 

  7. T. V. Lelekova, P. Ya. Romanovskii, P. N. Aleksandrov, and I. P. Ashmarin, Byull. Eksp. Biol. Med., 108, No. 7, 8-10 (1989).

    Google Scholar 

  8. V. G. Morozov, V. Kh. Khavinson, and V. V. Malinin, Peptide Thymomimetics [in Russian], St. Petersburg (2000).

  9. O. A. Ponomarev, I. P. Susak, E. E. Fesenko, and A. S. Shigaev, Biofizika, 47, No. 3, 395-410 (2002).

    Google Scholar 

  10. L. A. Sazanov and S. V. Zaitsev, Biokhimiya, 57, No. 10, 1443-1459 (1992).

    Google Scholar 

  11. V. Kh. Khavinson, E. G. Rybakina, V. V. Malinin, et al., Byull. Eksp. Biol. Med., 133, No. 5, 574-577 (2002).

    Google Scholar 

  12. E. E. Fesenko, V. I. Popov, V. V. Novikov, and S. S. Khutsyan, Biofizika, 47, No. 3, 389-394 (2002).

    Google Scholar 

  13. P. P. Yamskova and I. A. Yamskov, Ros. Khim. Zh., 43, No. 3, 74-79 (1999).

    Google Scholar 

  14. V. Kh. Khavinson, N. Goncharova, and B. Lapin, Neuroendocrinol. Lett., 22, 251-254 (2001).

    Google Scholar 

  15. B. P. Roques, J. Peptide Sci., 7, No. 7, 63-73 (2001).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. I. Grigor'ev.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grigor'ev, E.I., Khavinson, V.K., Malinin, V.V. et al. Role of Aqueous Medium in Mechanisms Underlying the Influence of Immunoactive Peptides in Ultralow Doses. Bulletin of Experimental Biology and Medicine 136, 150–154 (2003). https://doi.org/10.1023/A:1026362706175

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1026362706175

Navigation