Abstract
Purpose: The objective of the matched, controlled study was to determine whether low-dose aspirin therapy without heparin improves pregnancy rates following frozen embryo transfer.
Methods: Thirty-six women who did not achieve a pregnancy following fresh embryo transfer and who had frozen embryos available for another transfer were included. Eighteen women were treated with 81 mg aspirin from day 2 of the cycle through pregnancy testing. If the β-human chorionic gonadotropin level was positive, aspirin was continued through the pregnancy. Eighteen women were not given aspirin. The mean outcome variables were pregnancy and implantation rates.
Results: The clinical pregnancy rate in the aspirin group was 11.1%, compared with 33.3% for the controls, and implantation rates were 2.9 and 10.9%, respectively.
Conclusions: No positive effects of low-dose aspirin therapy on pregnancy rates following frozen embryo transfer were observed.
Similar content being viewed by others
REFERENCES
Sher G, Feinman M, Zouves C, Kuttner G, Maassarani G, Salem R, Matzner W, Ching W, Chong P: High fecundity rates following in-vitro fertilization and embryo transfer in antiphospholipid antibody seropositive women treated with heparin and aspirin. Hum Reprod 1994;9:2278–2283
Schenk LM, Butler L, Monis JP, Cox B, Leete J, Abuhamed A, Oehninger S, Muasher S: Heparin and aspirin treatment yields higher implantation rates in IVF patients with antiphospholipid antibody seropositivity compared to untreated seronegative patients. Fifty-Second Annual Meeting of the American Society for Reproductive Medicine, Nov 2-6, 1996
Kutteh WH, Yetman DL, Chantilis SJ, Byrd W, Crain J, Murty GS: Increased occurrence of early pregnancy loss associated with the presence of anticardiolipin antibodies (ACA) in women undergoing IVF. Fifty-Second Annual Meeting of the American Society for Reproductive Medicine, Nov 2-6, 1996
Wada I, Hsu CC, Williams G, Macnamee MC, Brinsden PR: The benefits of low-dose aspirin therapy in women with impaired uterine perfusion during assisted conception. Hum Reprod 1994:9:1954–1957
Baker AF, Check JH, Hourani CL: Survival and pregnancy rates of pronuclear stage human embryos cryopreserved and thawed using a single step addition and removal of cryoprotectant. Hum Reprod Update 2 (CD-ROM), item 12
Check JH, Hoover L, Nazari A, O'Shaughnessy A, Summers D: The effect of assisted hatching on pregnancy rates after frozen embryo transfer. Fertil Steril 1996;65:254–257
Weckstein LN, Jacobson A, Galen D, Hampton K, Hammel J: Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study. Fertil Steril 1997;68:927–930
Check JH, Nowroozi K, Choe J, Dietterich C: Influence of endometrial thickness and echo patterns on pregnancy rates during in vitro fertilization. Fertil Steril 1991;56:1173–1175
Check JH, Nowroozi K, Choe J, Lurie D, Dietterich C: The effect of endometrial thickness and echo pattern on in vitro fertilization outcome in donor oocyte-embryo transfer cycle. Fertil Steril 1993;59:72–75
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Check, J.H., Dietterich, C., Lurie, D. et al. A Matched Study to Determine Whether Low-Dose Aspirin Without Heparin Improves Pregnancy Rates Following Frozen Embryo Transfer and/or Affects Endometrial Sonographic Parameters. J Assist Reprod Genet 15, 579–582 (1998). https://doi.org/10.1023/A:1020373009043
Issue Date:
DOI: https://doi.org/10.1023/A:1020373009043