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Individual Sensitivity to Genotoxic Effects of Nickel and Antimutagenic Activity of Ascorbic Acid

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Abstract

Cytotoxicity of nickel compounds was studied by stimulating the repair synthesis of DNA and counting lymphocyte micronuclei in workers of smelting shop of copper-nickel sulfide processing plant. Nickel content in the organism was evaluated by its concentrations in hair. Therapy with ascorbic acid (1 g/day for 1 month) led to a significant decrease in the number of micronuclei. The number of micronuclei before and after ascorbic acid treatment varied within a wide range in different individuals.

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Authors and Affiliations

  1. Group of Medical Ecological Studies, Institute of Industrial Ecology Problems of the North, Karelian Research Center, Russian Academy of Sciences, Apatity

    I. N. Perminova, T. A. Sinel'shchikova, E. V. Perminova & G. D. Zasukhina

  2. Laboratory of Mutagenesis and Repair, N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow

    I. N. Perminova, T. A. Sinel'shchikova, E. V. Perminova & G. D. Zasukhina

Authors
  1. I. N. Perminova
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  2. T. A. Sinel'shchikova
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  3. N. I. Alekhina
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  4. E. V. Perminova
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  5. G. D. Zasukhina
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Perminova, I.N., Sinel'shchikova, T.A., Alekhina, N.I. et al. Individual Sensitivity to Genotoxic Effects of Nickel and Antimutagenic Activity of Ascorbic Acid. Bulletin of Experimental Biology and Medicine 131, 367–370 (2001). https://doi.org/10.1023/A:1017912521543

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  • DOI: https://doi.org/10.1023/A:1017912521543

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