Skip to main content
SpringerLink
Log in

Spectrum of Autoantibodies in Celiac Patients and Relatives

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

The coexistence of celiac disease together with a range of autoimmune disorders has already been reported. The aims of this study were to perform a broad spectrum of autoantibodies in celiac patients (N = 56), their first-degree relatives (N = 118), and compare the data with healthy controls (N = 101) and patients with inflammatory bowel disease (N = 42; Crohn's disease, N = 18 and ulcerative colitis, N = 24). All serum samples were tested by indirect immunofluorescence to the anti-endomysium antibodies (EmA), anti-neutrophil cytoplasmic (ANCA), anti-smooth-muscle (SMA), anti-mitochondrial (AMA), anti-nuclear (ANA), anti-liver–kidney microsomal (LKM), anti-gastric parietal cells (GPCA), and anti-thyroid microsome (TMA). EmA were detected in 100% of celiac patients ingesting gluten and in 16.1% of the first-degree relatives, while ANCA were positive only in patients with ulcerative colitis (45.6%) and Crohn's disease (16.5%). Fourteen CD patients (25%) were positive for at least one of the other autoantibodies, with significant prevalence of TMA, ANA, and GPCA, while the relatives showed 17.8% of positivity, with an increased prevalence of ANA and TMA. These results emphasize the value of screening for different autoantibodies in celiac patients and their relatives and corroborate the need for evaluation and follow-up of these individuals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Detlef S: Special concepts of celiac disease pathogenesis. Gastroenterology 119(1):234–242, 2000

    Google Scholar 

  2. Kotze LMS, Utiyama SRR, Nisihara RM, Mocelim V, Carvalho RFA, Zeni MPB, Amarante HMS: Comparac¸£o dos anticorpos anti-reticulina e antiendomisio classe IgA para diagnó stico e controle da dieta na Doença Celíca Gastroenterol 36(4):177–183, 1999

    Google Scholar 

  3. Sategna-Guidetti C, Bruno M, Mazza E, Carlino A, Predebon S, Tagliabue M, Brossa C: Autoimmune thyroid diseases and coeliac disease. Eur J Gastroenterol Hepatol 10(11):927–931, 1998

    Google Scholar 

  4. Sheehan NJ, Stanton-King K: Polyautoimmunity in a young woman. Br J Rheumatol 32(3):254–256, 1993

    Google Scholar 

  5. Kingham JG, Parker DR: The association between primary biliary cirrhosis and coeliac disease: A study of relative prevalences. Gut 42(1):120–122, 1998

    Google Scholar 

  6. Mukamel M; Rosenbach Y, Zahavi I, Mimouni M, Dinari G: Celiac disease associated with systemic lupus erythematosus. Isr J Med Sci 30(8):656–658, 1994

    Google Scholar 

  7. Galli-Tsinopoulou A, Nousia-Arvanitakis S, Dracoulacos D, Xefteri M, Karamouzis M: Autoantibodies predicting diabetes mellitus type I in celiac disease. Horm Res 52(3):119–124, 1999

    Google Scholar 

  8. Vitoria JC, Castano L, Rica I, Bilbao JR, Arrieta A, Garcia-Masdevall: Association of insulin-dependent diabetes mellitus and celiac disease: A study based on serologic markers. J Pediatr Gastroenterol Nutr 27(1):47–52, 1998

    Google Scholar 

  9. Volta U, De Franceschi L, Molinaro N, Tetta C, Bianchi FB: Organ-specific autoantibodies in coeliac disease: Do they represent an epiphenomenon or the expression of associated autoimmune disorders?. Ital J Gastroenterol Hepatol 29(1):18–21, 1997

    Google Scholar 

  10. Velluzzi F, Caradonna A, Boy MF, Pinna MA, Cabula R, Lai MA, Pira-Corda G, Mossa P, Atzeni F, Loviselli A, Usai P, Mariotti S: Thyroid and celiac disease: Clinical, serological, and echograph study. Am J Gastroenterol 93(6):976–979, 1998

    Google Scholar 

  11. Kaukinen K, Collin P, Mykkanen AH, Partanen J, Maki M, Salmi J: Celiac disease and autoimmune endocrinologic disorders. Dig Dis Sci 44(7):1428–1433, 1999

    Google Scholar 

  12. Cuoco L, Certo M, Jorizzo RA, De Vitis I, Tursi A, Papa A, De Marinis L, Fedeli G, Gasbarrini G: Prevalence and early diagnosis of coeliac disease in autoimmune thyroid disorders. Ital J Gastroenterol Hepatol 31(4):283–287, 1999

    Google Scholar 

  13. Volta U, De Franceschi L, Molinaro N, Cassani F, Muratori L, Lenzi M, Bianchi FB, Czaja AJ: Frequency and significance of anti-gliadin and anti-endomysial antibodies in autoimmune hepatitis. Dig Dis Sci 43(10):2190–2195, 1998

    Google Scholar 

  14. Hodges S, Lobo-Yeo A, Donaldson P, Tanner MS, Vergani D: Autoimmune chronic active hepatitis in a family. Gut 326(3):299–302, 1991

    Google Scholar 

  15. Sorensen HT, Thulstrup AM, Blomqvist P, Norgaard B, Fonager K, Ekbom A: Risk of primary biliary liver cirrhosis in patients with coeliac disease: Danish and Swedish cohort data: Gut 44(5):736–738, 1999

    Google Scholar 

  16. Varkel Y, Braester A, Suprun H, Nusem D, Horn Y: Simultaneous occurrence of systemic lupus erythematosus and coeliac disease-like features. Postgrad Med J 65(7666):600–602, 1989

    Google Scholar 

  17. Niveloni S, Pedreira S, Sugai E, Vazquez H, Smecuol E, Fiorini A, Cab A, Dezi R, Valero J, Kogan Z, Maurino E, Bai JC: The natural history of gluten sensivity: Report of two new celiac disease patients resulting from a long-term follow-up of nonatrophic first-degree relatives. Am J Gastroenterol 95(2):463–468, 2000

    Google Scholar 

  18. Ventura A, Magazzu G, Greco L: Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. Gastroenterology 1176(2):297–303, 1999

    Google Scholar 

  19. Vilppula AH, Aine RA: Polymyositis associated with several immunological disorders. Clin Rheumatol 3(4):533–539, 1984

    Google Scholar 

  20. Toscano V, Conti FG, Anastasi E, Mariani P, Tiberti C, Poggi M, Monruori M, Monti S, Laureti S, Cipolletta E, Gemme G, Caiola S, Di Mario U, Bonamico M: Importance of gluten in the induction of endocrine autoantibodies and organ dysfunction in adolescent celiac patients. Am J Gastroenterol 95(7):1742–1748, 2000

    Google Scholar 

  21. Berti I, Trevisiol C, Tommasini A, Citta A, Neri E, Geatti O, Giammar, Ventura A, Not T: Usefulness of screening program for celiac disease in autoimmune thyroiditis. Dig Dis Sci 45(2):403–406, 2000

    Google Scholar 

  22. Walker-Smith JA, Guandalini S, Schimitz J, Shmerling Visakorpi JK: Revised criteria for diagnosis of coeliac disease. Arch Dis Child 65:909–911, 1990

    Google Scholar 

  23. Bigazzi PE, Rose NR: Pruebas para anticuerpos contra antigenos tissulares especificos. In: El Laboratorio en Immunologia Clínica, 2nd ed. Editorial Medica Pan Americana, 1984, pp 968–979

  24. Rizzeto M, Swana G, Doniach D: Microsomal antibodies in active active chronic hepatitis and other disorders. Clin Exp Immunol 15:331–344, 1973

    Google Scholar 

  25. Wiik A: Delineation of a standard procedure for indirect immunofluorescence detection of ANCA. APMIS(suppl 6):12–13, 1989

    Google Scholar 

  26. Ladinser B, Rossipal E, Pittscheier K: Endomysium antibodies in coeliac disease: An improved method. Gut 35:776–778, 1994

    Google Scholar 

  27. Volta U, Molinaro N, De Franceschi L, Fratangelo D, Bianchi FB: IgA anti-endomysial antibodies on human umbilical cord tissue for celiac disease screening. Dig Dis Sci 40(9):1902–1905, 1995

    Google Scholar 

  28. Lerner A, Blank M, Lahat N, Shoenfeld Y: Increased prevalence of autoantibodies in celiac disease. Dig Dis Sci 43(4):723–726, 1998

    Google Scholar 

  29. Vecchi M, Bianchi MB, Sinico RA, Radice A, Meucci G, Torgano G, Omodei P, Forzenigo L, Landoni M, Arrigoni M: Antibodies to neutrophil cytoplasm in Italian patients with ulcerative colitis: Sensitivity, specificity and recognition of putative antigens. Digestion 556(1):34–39, 1994

    Google Scholar 

  30. Boudraa G, Hachelaf W, Benbouabdellah M, Belkadi M, Benmansour FZ, Touchami M: Prevalence of coeliac disease in diabetic children and their first-degree relatives in west Algeria: Screening with serological markers. Acta Paediatr Suppl 412:58–60, 1996

    Google Scholar 

  31. Komatireddy GR, Marshall JB, Aqel R, Spollen LE, Sharp GC: Association of systemic lupus erythematosus and gluten enteropathy. South Med J 88(6):673–676, 1995

    Google Scholar 

  32. Sjoberg K, Lindgren S, Eriksson S: Frequent occurrence of non-specific gliadin antibodies in chronic liver disease. Endomysial but not gliadin antibodies predict coeliac disease in patients with chronic liver disease. Scand J Gastroenterol 32(11):1162–1167, 1997

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Immunopathology, Department of Medical Pathology, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil

    Shirley Ramos da Rosa Utiyama, Renato Mitsunori Nisihara, Roberta Ferreira Carvalho, Elisandra Grangeiro de Carvalho & Iara José Taborda De Messias Reason

  2. Division of Gastroenterology and Digestive Endoscopy, Cajuru Hospital, Pontifical Catholic University of Paraná, Curitiba, Brazil

    Lorete Maria da Silva Kotze

  3. Division of Gastroenterology, Federal University of Paraná, Curitiba, Brazil

    Margareth Gomes de Sena

Authors
  1. Shirley Ramos da Rosa Utiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lorete Maria da Silva Kotze
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Renato Mitsunori Nisihara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Roberta Ferreira Carvalho
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Elisandra Grangeiro de Carvalho
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Margareth Gomes de Sena
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Iara José Taborda De Messias Reason
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Utiyama, S.R.d.R., Kotze, L.M.d.S., Nisihara, R.M. et al. Spectrum of Autoantibodies in Celiac Patients and Relatives. Dig Dis Sci 46, 2624–2630 (2001). https://doi.org/10.1023/A:1012702807714

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1012702807714

Search

Navigation