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Case–control study of alcohol consumption and prostate cancer risk in Montréal, Canada

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Abstract

Objectives: to estimate the risk of prostate cancer associated with alcohol consumption.

Methods: Between 1979 and 1985 a population-based case–control study was carried out in Montréal, which accrued over 4000 men in total, including cases of prostate cancer, other cancers, and population controls. The present analysis was restricted to the subset, aged 45–70 years, who underwent face-to-face interviews, in which aspects of lifelong alcohol consumption were ascertained. The cancer control series was further restricted to men whose tumor types were considered unrelated to alcohol consumption. There were 399 incident cases of prostate cancer, 476 population controls, and 674 cancer controls.

Results: When using the population controls, risk increased with increasing cumulative consumption of alcohol. There was no decrease in risk after quitting. Risk was particularly high among those who reported having started before age 15 years (odds ratio = 3.8; 95% confidence interval: 1.6–9.3). The results obtained using the cancer controls were less pronounced, but still indicated an excess risk associated with alcohol consumption. Beer was the most prevalent type of alcohol consumed in this population and showed the strongest association with prostate cancer.

Conclusions: The results are consistent with an increase in the risk of prostate cancer due to alcohol consumption.

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References

  1. Key T (1995) Risk factors for prostate cancer. Cancer Surv 23: 63–77.

    Google Scholar 

  2. Giovannucci E (1995) Epidemiologic characteristics of prostate cancer. Cancer 75(Suppl. 7): 1766–1777.

    Google Scholar 

  3. Colditz G (1996) Consensus conference: smoking and prostate cancer. Cancer Causes Control 7: 560–562.

    Google Scholar 

  4. Breslow RA, Weed DL (1998) Review of epidemiologic studies of alcohol and prostate cancer: 1971–1996. Nutr Cancer 30: 1–13.

    Google Scholar 

  5. Siemiatycki J, Richardson L (1991) Case-control design and fieldwork methods. In: Siemiatycki J, ed. Risk Factors for Cancer in the Workplace. Boca Raton, FL: CRC Press, pp. 29–44.

    Google Scholar 

  6. Linet MS, Brookmeyer R (1987) Use of cancer controls in case-control studies. Am J Epidemiol 125: 1–11.

    Google Scholar 

  7. Richardson L (1985) Case-control study methods: response rates, respondent characteristics and nonresponse bias. MSc thesis. Montréal: McGill University, p. 97.

    Google Scholar 

  8. Siemiatycki J, Dewar R (1991) Statistical methods. In: Siemiatycki J, ed. Risk Factors for Cancer in the Workplace. Boca Raton, FL: CRC Press, pp. 116–118.

    Google Scholar 

  9. Jensen OM, Paine SL, McMichael AJ, Ewertz M (1996) Alcohol. In: Schottenfeld D, Fraumeni JF, eds. Cancer Epidemiology and Prevention, 2nd edn. New York: Oxford University Press, pp. 290–318.

    Google Scholar 

  10. Siemiatycki J, Krewski D, Franco E, Kaiserman M (1995) Associations between cigarette smoking and each of 21 types of cancer: a multi-site case-control study. Int J Epidemiol 24: 504–514.

    Google Scholar 

  11. Skinner HA, Holt S, Israel Y (1981) Early identification of alcohol abuse: 1. Critical issues and psychosocial indicators for a composite index. Can Med Assoc J 124: 1141–1152.

    Google Scholar 

  12. Breslow NE, Day NE (1980) Statistical Methods in Cancer Research, Vol. 1: The Analysis of Case-Control Studies. IARC Scientific Publication. No. 32. Lyon: International Agency for Research on Cancer, pp. 192–246.

    Google Scholar 

  13. SAS Institute Inc. 1997. SAS/STAT Software: Changes and Enhancements Throught Release 6.12. Cary, NC: SAS Institute Inc. pp. 871–948.

    Google Scholar 

  14. Brenner H, Gefeller O (1993) Use of positive predictive value to correct for disease misclassification in epidemiologic studies. Am J Epidemiol 138: 1007–1015.

    Google Scholar 

  15. Van der Gulden JWJ, Verbeek ALM, Kolk JJ (1994) Smoking and drinking habits in relation to prostate cancer. Br J Urol 73: 382–389.

    Google Scholar 

  16. Adami H-O, McLaughlin JK, Hsing AW, et al. (1992) Alcoholism and cancer risk: a population-based cohort study. Cancer Causes Control 3: 419–425.

    Google Scholar 

  17. Tonnesen H, Moller H, Andersen JR, Jensen E, Juel K (1994) Cancer morbidity in alcohol abusers. Br J Cancer 69: 327–332.

    Google Scholar 

  18. Hayes RB, Brown LM, Schoenberg JB, et al. (1996) Alcohol use and prostate cancer risk in US blacks and whites. Am J Epidemiol 143: 692–697.

    Google Scholar 

  19. Putnam SD, Cerhan JR, Parker AS, et al. (2000) Lifestyle and anthropometric risk factors for prostate cancer in a cohort of Iowa men. Ann Epidemiol 10: 361–369.

    Google Scholar 

  20. Andersson BO, Baron J, Bergström R, Lindgren C, Wolk A, Adami HO (1996) Lifestyle factors and prostate cancer risk: a case-control study in Sweden. Cancer Epidemiol Biomarkers Prev 5: 509–513.

    Google Scholar 

  21. Cerhan JR, Torner JC, Lynch CF, et al. (1997) Association of smoking, body mass, and physical activity, with risk of prostate cancer in the Iowa 65+ Rural Health Study (United States). Cancer Causes Control 8: 229–238.

    Google Scholar 

  22. Key TJA, Silcocks PB, Davey GK, Appleby PN, Bishop DT (1997) A case-control study of diet and prostate cancer. Br J Cancer 76: 678–687.

    Google Scholar 

  23. Jain MG, Hislop GT, Howe GR, Burch JD, Ghadirian P (1998) Alcohol and other beverage use and prostate cancer risk among Canadian men. Int J Cancer 78: 707–711.

    Google Scholar 

  24. Lumey LH, Pittman B, Wynder EL (1998) Alcohol use and prostate cancer in U.S. whites: no association in a confirmatory study. Prostate 36: 250–255.

    Google Scholar 

  25. Schuurman AG, Goldbohm RA, van den Brandt PA (1999) A prospective cohort study on consumption of alcoholic beverages in relation to prostate cancer incidence (The Netherlands). Cancer Causes Control 10: 597–605.

    Google Scholar 

  26. Breslow RA, Wideroff L, Graubard BI, et al. (1999) Alcohol and prostate cancer in the NHANES I epidemiologic follow-up study. Ann Epidemiol 9: 254–261.

    Google Scholar 

  27. Hsieh CC, Thanos A, Mitropoulos D, Deliveliotis C, Mantzoros CS, Trichopoulos D (1999) Risk factors for prostate cancer: a case-control study in Greece. Int J Cancer 80: 699–703.

    Google Scholar 

  28. Villeneuve PJ, Johnson KC, Kreiger N, Mao Y, and The Canadian Cancer Registries Epidemiology Research Group (1999) Risk factors for prostate cancer: results from the Canadian National Enhanced Cancer Surveillance System. Cancer Causes Control 10: 355–367.

    Google Scholar 

  29. Ellison LF (2000) Tea and other beverage consumption and prostate cancer risk: a Canadian retrospective cohort study. Eur J Cancer Prev 9: 125–130.

    Google Scholar 

  30. Lund Nilsen TI, Johnsen R, Vatten LJ (2000) Socio-economic and lifestyle factors associated with the risk of prostate cancer. Br J Cancer 82: 1358–1363.

    Google Scholar 

  31. Dennis LK (2000) Meta-analysis for combining relative risks of alcohol consumption and prostate cancer. Prostate 42: 56–66.

    Google Scholar 

  32. Embree BG, Whitehead PC (1993) Validity and reliability of self-reported drinking behaviour: dealing with the problem of response bias. J Stud Alcohol 54: 334–344.

    Google Scholar 

  33. Pitot HC (1996) Stages in neoplastic development. In: Schottenfeld D, Fraumeni JF, eds. Cancer Epidemiology and Prevention, 2nd edn. New York: Oxford University Press, pp. 65–79.

    Google Scholar 

  34. Hayward SW, Cunha GR, Dahiya R (1996) Normal development and carcinogenesis of the prostate. A unifying hypothesis. Ann NY Acad Sci 784: 50–62.

    Google Scholar 

  35. De Stefani E, Fierro L, Barrios E, Ronco A (1995) Tobacco, alcohol, diet and risk of prostate cancer. Tumori 81: 315–320.

    Google Scholar 

  36. International Agency for Research on Cancer (1988) IARC Monogr Eval Careinog Risk Humans. Alcohol Drinking, vol. 44. Lyon: IARC, pp. 101–152.

    Google Scholar 

  37. Chan JM, Stampfer MJ, Giovannucci E, et al. (1998) Plasma insulin-like growth factor-1 and prostate cancer risk: a prospective study. Science 279: 563–566.

    Google Scholar 

  38. Goodman-Gruen D, Barrett-Connor E (1997) Epidemiology of insulin-like growth factor-1 in elderly men and women. The Rancho Bernardo study. Am J Epidemiol 145: 970–976.

    Google Scholar 

  39. Kaklamani VG, Linos A, Kaklamani E, Markaki I, Mantzoros C (1999) Age, sex, and smoking are predictors of circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3. J Clin Oncol 17: 813–817.

    Google Scholar 

  40. Health and Welfare Canada, Statistics Canada (1981) Alcohol use. In: The Health of Canadians. Report of the Canada Health Survey. Ottawa: Minister of Supply and Services Canada, pp. 23–41.

    Google Scholar 

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Authors and Affiliations

  1. INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Quebec, Canada

    Colin R. Sharpe & Jack Siemiatycki

  2. Joint Departments of Epidemiology and Biostatistics and of Occupational Health, McGill University, Montréal, Québec, Canada

    Jack Siemiatycki

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  1. Colin R. Sharpe
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  2. Jack Siemiatycki
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Sharpe, C.R., Siemiatycki, J. Case–control study of alcohol consumption and prostate cancer risk in Montréal, Canada. Cancer Causes Control 12, 589–598 (2001). https://doi.org/10.1023/A:1011289108040

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  • DOI: https://doi.org/10.1023/A:1011289108040

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