Abstract
The inverted terminal repeat (ITR) of the genome of four bovine adenovirus (BAdV) types have been sequenced, analysed and compared to the ITRs of other adenoviruses. The length of ITRs of the examined BAdVs ranged between 59 and 368 base pairs, thus the presently known longest adenovirus ITR sequence is from BAdV-10. The conserved motifs and characteristic sequence elements of the ITRs providing different binding sites for replicative proteins of viral and cellular origin seemed to be distributed according to the proposed genus classification of BAdVs. The ITRs of BAdV-10 share similarity with the members of the genus Mastadenovirus, while the ITRs of the other three sequenced serotypes (BAdV-4, 5 and strain Rus) which are candidate members of the genus Atadenovirus are very short and contain NFI and Sp1 binding sites only. The analysis of the new ITRs implied that the nucleotide sequence of the so-called core origin is highly preserved within the mastadenovirus genus only.
Similar content being viewed by others
References
Benkö M., Harrach B., and Russell W.C., in Van Regenmortel M.H.V., Fauquet C.M., Bishop D.H.L., Carstens E., Estes M., Lemon S., Maniloff J., Mayo M.A., McGeoch D., Pringle C., Wickner R. (eds). Virus Taxonomy. Seventh Report of the International Committee on Taxonomy of Viruses, Academic Press, New York, San Diego, 2000, pp. 227-238.
Vrati S., Brookes D.E., Strike P., Khatri A., Boyle D.B., and Both G.W., Virology 220, 186-199, 1996.
Harrach B., Meehan B.M., Benkö M., Adair B.M., and Todd D., Virology 229, 302-308, 1997.
Hess M., Blöcker H., and Brandt P., Virology 238, 145-156, 1997.
Dán Á., Ruzsics Z., Russell W.C., Benkö M., and Harrach B., J Gen Virol 79, 1453-1460, 1998.
Harrach B. and Benkö M., in Wold W.S.M. (ed). Adenovirus Methods and Protocols, Humana Press Inc., Totowa, NJ, 1998, pp. 309-339.
Benkö M. and Harrach B., Arch Virol 143, 829-837, 1998.
Matiz K., Ursu K., Harrach B., Zádori Z., and Benkö M., Virus Res 55, 29-35, 1998.
Zakharchuk A.N., Kruglyak V.A., Akopian T.A., Naroditsky B.S., and Tikchonenko T.I., Arch Virol 128, 171-176, 1993.
Van der Vliet P.C., in Doerfler W., and Böhm P. (eds). The Molecular Repertoire of Adenoviruses, vol. 2, Springer-Verlag, Köln, 1995, pp. 1-30.
Hay R.T., Freeman A., Leith I., Monaghan A., and Webster A., in Doerfler W., and Böhm P. (eds). The Molecular Repertoire of Adenoviruses, vol. 2, Springer-Verlag, Köln, 1995, pp. 31-48.
Mul Y.M., Verrijzer C.P., and van der Vliet P.C., J Virol 64, 5510-5518, 1990.
Hatfield L. and Hearing P., J Virol 67, 3931-3939, 1993.
Benkö M., Harrach B., and D'Halluin J., J Gen Virol 71, 465-469, 1990.
Reddy P.S., Tuboly T., Dennis J.R., Derbyshire J.B., and Nagy É., Virology 212, 237-239, 1995.
Akopian T.A., Doronin K.K., Zakharchuk A.N., and Naroditsky B.S., GenBank Deposit. Accession number Z86066.
Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., and Cotten M., J Virol 70, 2939-2949, 1996.
Sheppard M. and Erny K.M., Nucleic Acids Res 17, 3995, 1989.
Pitcovski J., Mualem M., Rei-Koren Z., Krispel S., Shmueli E., Peretz Y., Gutter B., Gallili G.E., Michael A., and Goldberg D., Virology 249, 307-315, 1998.
Challberg M.D. and Rawlins D.R., Proc Natl Acad Sci USA 81, 100-104, 1984.
Harris M.P. and Hay R.T., J Mol Biol 201, 57-67, 1988.
Shinagawa M., Iida Y., Matsuda A., Tsukiyama T., and Sato G., Gene 55, 85-93, 1987.
Fitzgerald L., Ansari M., and Haj-Ahmad Y., Gene 185, 181-186, 1997.
Temperley S.M., Burrow C.R., Kelly T.J., and Hay R.T., J Virol 65, 5037-5044, 1991.
Shinagawa M., Ishiyama T., Padmanabhan R., Fujinaga K., Kamada M., and Sato G., Virology 125, 491-495, 1983.
Cao J.X., Krell P.J., and Nagy E., J Gen Virol 79, 2507-2516, 1998.
Alestrom P., Stenlund A., Li P., Bellett A., and Pettersson U., J Virol 42, 306-310, 1982.
Akopian T.A., Kruglyak V.A., Rivkina M.B., Naroditsky B.S., and Tikhonenko T.I., Nucleic Acids Res 18, 2825, 1990.
de Vries E., van Driel W., Tromp M., van Boom J., and van der Vliet P.C., Nucleic Acids Res 13, 4935-4952, 1985.
Leegwater P.A., van Driel W., and van der Vliet P.C., EMBO J 4, 1515-1521, 1985.
Pruijn G.J., van Miltenburg R.T., Claessens J.A., and van der Vliet P.C., J Virol 62, 3092-3102, 1988.
Hatfield L. and Hearing P., Virology 184, 265-276, 1991.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dán, Á., Élő, P., Harrach, B. et al. Four New Inverted Terminal Repeat Sequences from Bovine Adenoviruses Reveal Striking Differences in the Length and Content of the ITRs. Virus Genes 22, 175–179 (2001). https://doi.org/10.1023/A:1008125324346
Issue Date:
DOI: https://doi.org/10.1023/A:1008125324346