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Progesterone Receptor Isoforms Expression Pattern in Human Chordomas

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Abstract

Steroid hormone receptors are involved in the regulation of tumor growth. Two progesterone receptor (PR) isoforms have been identified in humans: a larger form (PR-B) and the N-terminally truncated one (PR-A). PR isoforms can exert opposite functions and are differentially regulated by estrogens. PR have been detected in several brain tumors including chordomas, however, it is unknown which PR isoform is expressed in brain tumors. The aim of this study was to determine by reverse transcription-polymerase chain reaction (RT-PCR) and by immunohistochemistry the expression pattern of PR isoforms in chordomas as well as its correlation with the expression of estrogen receptor α (ER-α). All studied chordomas expressed both PR and ER-α. PR-B was the predominant isoform in chordomas both at the mRNA and at the protein level. These data suggest that PR-B should be the predominant PR isoform expressed in human chordomas.

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Authors and Affiliations

  1. Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico

    Ignacio Camacho-Arroyo, Gabriela González-Agüero & Marco A. Cerbón

  2. Departamento de Patología, Instituto Nacional de la Nutrición, Mexico City, México

    Armando Gamboa-Domínguez

  3. Departamento de Neurocirugía, Instituto Nacional de Neurología y Neurocirugía, Mexico City, México

    Rodolfo Ondarza

Authors
  1. Ignacio Camacho-Arroyo
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  2. Gabriela González-Agüero
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  3. Armando Gamboa-Domínguez
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  4. Marco A. Cerbón
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  5. Rodolfo Ondarza
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Camacho-Arroyo, I., González-Agüero, G., Gamboa-Domínguez, A. et al. Progesterone Receptor Isoforms Expression Pattern in Human Chordomas. J Neurooncol 49, 1–7 (2000). https://doi.org/10.1023/A:1006412000726

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