Abstract
An automated nanospray system based on chip technology (the NanoMate) was successfully interfaced to a modified Particle Discriminator Interface on a triple quadrupole mass spectrometer. A number of the interface parameters were optimized to improve the sampling efficiency for ions from the chip-based system. Analytical performance was assessed using a number of biochemicals as well as via a methodology for a pharmaceutical that passed validation as required by Good Laboratory Practices. Infusion analyses in flow rates <1 µL/min provided advantages in terms of throughput and sample consumption when compared to other methodologies based on liquid chromatography.
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Published online February 4, 2005
An erratum to this article is available at http://dx.doi.org/10.1016/j.jasms.2005.03.004.
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Corkery, L.J., Pang, H., Schneider, B.B. et al. Automated nanospray using chip-based emitters for the quantitative analysis of pharmaceutical compounds. J Am Soc Mass Spectrom 16, 363–369 (2005). https://doi.org/10.1016/j.jasms.2004.11.018
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DOI: https://doi.org/10.1016/j.jasms.2004.11.018