Sleep and Biological Rhythms

, Volume 15, Issue 2, pp 167–177

Unbalanced resting-state networks activity in psychophysiological insomnia

  • Daniel Ruivo Marques
  • Ana Allen Gomes
  • Vanda Clemente
  • José Moutinho dos Santos
  • Isabel Catarina Duarte
  • Gina Caetano
  • Miguel Castelo-Branco
Original Article

DOI: 10.1007/s41105-017-0096-8

Cite this article as:
Marques, D.R., Gomes, A.A., Clemente, V. et al. Sleep Biol. Rhythms (2017) 15: 167. doi:10.1007/s41105-017-0096-8

Abstract

Psychophysiological insomnia (PI) is a clinical condition characterized by sleep-related disturbing cognitive activity and biased self-related information processing. This hypothetical cognitive arousal has been hypothesized to be associated with overactivation within different brain areas and networks, especially when individuals are at rest, e.g., in the absence of any attention-demanding task. In this study, we carried out a resting-state fMRI experiment aimed at investigating activity of the different resting-state networks in PI. Our pool of participants was compound of 5 PI patients and 5 sex- and age-matched healthy controls recruited from the community. Participants from both groups also completed a set of self-report measures, including the sleep diary, Insomnia Severity Index (ISI), dysfunctional beliefs and attitudes about sleep (DBAS-30), and the World Health Organization Quality of Life Measure (WHOQOL-Bref). Our results showed that insomnia patients presented altered activation in the default-mode network (DMN), visual and auditory networks, and bilateral fronto-parietal networks. In the DMN, the patients presented a pattern of both decreased (right superior frontal gyrus, left medial frontal gyrus, and right middle temporal gyrus) and increased activation (left superior frontal gyrus, left anterior and posterior cingulate, right precuneus, left cingulate gyrus, and left middle temporal gyrus). Our findings on unbalanced resting-state networks in PI, with special emphasis on the DMN, may lay grounds to better understanding of the cognitive arousal experienced by PI patients and might help to further improve the clinical management of insomnia.

Keywords

Insomnia Resting-state networks Neural activation Default-mode network Neuroimaging fMRI 

Copyright information

© Japanese Society of Sleep Research 2017

Authors and Affiliations

  • Daniel Ruivo Marques
    • 1
    • 2
  • Ana Allen Gomes
    • 3
    • 4
  • Vanda Clemente
    • 5
  • José Moutinho dos Santos
    • 5
  • Isabel Catarina Duarte
    • 6
  • Gina Caetano
    • 2
    • 6
    • 7
  • Miguel Castelo-Branco
    • 2
    • 6
  1. 1.Department of Education and PsychologyUniversity of AveiroAveiroPortugal
  2. 2.Institute for Biomedical Imaging and Life SciencesIBILICoimbraPortugal
  3. 3.Faculty of Psychology and Educational SciencesUniversity of CoimbraCoimbraPortugal
  4. 4.Centro de Investigação do Núcleo de Estudos e Intervenção Cognitivo-Comportamental/Research and Development Unit (FCT), Cognitive and Behavioral Center for Research and InterventionCINEICCCoimbraPortugal
  5. 5.Sleep Medicine CentreCoimbra University Hospital Centre (CHUC)CoimbraPortugal
  6. 6.Brain Imaging NetworkICNASCoimbraPortugal
  7. 7.ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior TécnicoUniversidade de LisboaLisbonPortugal

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