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Analysis of US FDA-Approved Drugs Containing Sulfur Atoms

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Abstract

In this review, we discuss all sulfur-containing FDA-approved drugs and their structures. The second section of the review is dedicated to structural analysis and is divided into 14 subsections, each focusing on one type of sulfur-containing moiety. A concise graphical representation of each class features drugs that are organized on the basis of structural similarity, evolutionary relevance, and medical indication. This review offers a unique and comprehensive overview of the structural features of all sulfur-containing FDA-approved drugs to date.

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Abbreviations

6-APA:

6-Aminopenicillanic acid

ADP:

Adenosine diphosphate

cGMP:

Cyclic guanosine monophosphate

COX-2:

Cyclooxygenase-2

GERD:

Gastroesophageal reflux disease

GPCR:

G protein-coupled receptor

HIV:

Human immunodeficiency virus

mRNA:

Messenger RNA

NSAID:

Nonsteroidal anti-inflammatory drugs

SMN1:

Survival motor neuron 1

SMN2:

Survival motor neuron 2

PBP-3:

Penicillin binding protein 3

P2Y12 :

A type of purinergic receptor

PDE5:

Phosphodiesterase type 5

PET:

Positron emission tomography

PPI:

Proton pump inhibitor

US FDA:

United States Food and Drug Administration

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Acknowledgements

The funding was provided by National Science Foundation (Grant no. CHE-1565500).

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, 85721, USA

    Kevin A. Scott & Jon T. Njardarson

  2. Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, 85721, USA

    Kevin A. Scott

Authors
  1. Kevin A. Scott
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  2. Jon T. Njardarson
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Corresponding author

Correspondence to Jon T. Njardarson.

Additional information

This article is part of the Topical Collection “Sulfur Chemistry”, edited by Xuefeng Jiang.

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Scott, K.A., Njardarson, J.T. Analysis of US FDA-Approved Drugs Containing Sulfur Atoms. Top Curr Chem (Z) 376, 5 (2018). https://doi.org/10.1007/s41061-018-0184-5

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  • DOI: https://doi.org/10.1007/s41061-018-0184-5

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