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Synthesis of Some Novel 3-Spiro Monocyclic β-Lactams and Their Antibacterial and Antifungal Investigations

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Iranian Journal of Science and Technology, Transactions A: Science Aims and scope Submit manuscript

Abstract

A novel series of new 3-spiro monocyclic β-lactams 3a–i have been synthesized in high chemical yields from 9H-xanthene-9-carbonyl chloride 2 as ketene source in the [2+2] cycloaddition (Staudinger reaction) with different aromatic imines. These newly synthesized β-lactams were fully characterized and evaluated for their antimalarial activities against Plasmodium falciparum K14-resistant strain with moderate to excellent EC50 values varying from 8 up to 50 µM.

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Acknowledgments

The authors thank the Shiraz University Research Council for financial support (93-GR-SC-23).

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Authors and Affiliations

  1. Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454, Iran

    Aliasghar Jarrahpour & Shadab Rezaei

  2. UMR-MD3 Relation hôte-parasites, Physiopathologie and Pharmacologie, Faculté de Pharmacie, Aix-Marseille Université, Bd Jean Moulin, 13385, Marseille, France

    Véronique Sinou & Christine Latour

  3. UM 105, Inserm, U1068, Faculté de pharmacie, Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR7258, Institut Paoli Calmettes, Aix-Marseille Université, Bd Jean Moulin, 13385, Marseille, France

    Jean Michel Brunel

Authors
  1. Aliasghar Jarrahpour
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  2. Shadab Rezaei
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  3. Véronique Sinou
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  4. Christine Latour
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  5. Jean Michel Brunel
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Correspondence to Aliasghar Jarrahpour.

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Jarrahpour, A., Rezaei, S., Sinou, V. et al. Synthesis of Some Novel 3-Spiro Monocyclic β-Lactams and Their Antibacterial and Antifungal Investigations. Iran J Sci Technol Trans Sci 41, 337–342 (2017). https://doi.org/10.1007/s40995-016-0033-8

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  • DOI: https://doi.org/10.1007/s40995-016-0033-8

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