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Fetal Alcohol Spectrum Disorders: a Case Study

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Abstract

This grand rounds manuscript reviews important considerations in developing case conceptualizations for individuals with a history of prenatal alcohol exposure. This case study provides an introduction to fetal alcohol spectrum disorders, diagnostic issues, a detailed description of the individual’s history, presenting symptoms, neuropsychological test results, and an integrated summary. We describe a 9-year-old girl diagnosed with a fetal alcohol spectrum disorder (FASD): Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE). This patient is a composite of a prototypical child who participated as part of a research project at the Center for Behavioral Teratology who was subsequently seen at an outpatient child psychiatry facility.

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References

  • Achenbach, T.M., & Rescorla, L.A. (2001). Manual for the ASEBA school-age forms & profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families.

  • Adnams, C. M., Sorour, P., Kalberg, W. O., Kodituwakku, P., Perold, M. D., Kotze, A., & May, P. A. (2007). Language and literacy outcomes from a pilot intervention study for children with fetal alcohol spectrum disorders in South Africa. Alcohol, 41(6), 403–414. doi:10.1016/j.alcohol.2007.07.005.

    Article  PubMed  PubMed Central  Google Scholar 

  • American Academy of Pediatrics. (2000). Committee on substance abuse and committee on children with disabilities. Fetal alcohol syndrome and alcohol-related neurodevelopmental disorders. Pediatrics, 106, 358–361.

    Article  Google Scholar 

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, DSM-5 (5th ed.). Arlington, VA: American Psychiatric Publishing, Inc.

    Book  Google Scholar 

  • Astley, S. J., Clarren, S. K. (2000). Diagnosing the full spectrum of fetal alcohol-exposed individuals: Introducing the 4-digit diagnostic code. Alcohol and Alcoholism 35(4), 400–410, PMID: 10906009.

  • Autti-Ramo, I. (2000). Twelve-year follow-up of children exposed to alcohol in utero. Developmental Medicine and Child Neurology, 42(6), 406–411.

    Article  PubMed  Google Scholar 

  • Bell, S. H., Stade, B., Reynolds, J. N., Rasmussen, C., Andrew, G., Hwang, P. A., & Carlen, P. L. (2010). The remarkably high prevalence of epilepsy and seizure history in fetal alcohol spectrum disorders. Alcoholism, Clinical and Experimental Research, 34(6), 1084–1089. doi:10.1111/j.1530-0277.2010.01184.x.

    Article  PubMed  Google Scholar 

  • Bertrand, J., Floyd, R. L., Weber, M. K., et al. (2004). National task force on fetal alcohol syndrome and fetal alcohol effect. Fetal alcohol syndrome: Guidelines for referral and diagnosis. Atlanta, GA: Centers for Disease Control and Prevention (CDC).

  • Bertrand, J., Floyd, L. L., & Weber, M. K. (2005). Fetal alcohol syndrome prevention team, division of birth defects, developmental disabilities, national center on birth defects, developmental disabilities, centers for disease control, & prevention. Guidelines for identifying and referring persons with fetal alcohol syndrome. MMWR - Recommendations and Reports, 54(RR-11), 1–14.

    PubMed  Google Scholar 

  • Bhatara, V., Loudenberg, R., & Ellis, R. (2006). Association of attention deficit hyperactivity disorder and gestational alcohol exposure: an exploratory study. Journal of Attention Disorders, 9(3), 515–522. doi:10.1177/1087054705283880.

    Article  PubMed  Google Scholar 

  • Boys, C. J., Bjorke, J., Dole, K. D., Dalnes, C., Terwey, S., & Chang, P.-N. (2016). Improving educational outcomes in fetal alcohol spectrum disorder through interagency collaboration. Journal of Pediatric Neuropsychology, 2(1), 50–57.

    Article  Google Scholar 

  • Burd, L., Klug, M. G., Martsolf, J. T., & Kerbeshian, J. (2003). Fetal alcohol syndrome: neuropsychiatric phenomics. Neurotoxicology and Teratology, 25(6), 697–705. doi:10.1016/j.ntt.2003.07.014.

    Article  PubMed  Google Scholar 

  • Carr, J. L., Agnihotri, S., & Keightley, M. (2010). Sensory processing and adaptive behavior deficits of children across the fetal alcohol spectrum disorder continuum. Alcoholism, Clinical and Experimental Research, 34(6), 1022–1032. doi:10.1111/j.1530-0277.2010.01177.x.

    Article  PubMed  Google Scholar 

  • Chasnoff, I. J., Wells, A. M., & King, L. (2015). Misdiagnosis and missed diagnoses in foster and adopted children with prenatal alcohol exposure. Pediatrics. doi:10.1542/peds.2014-2171.

    PubMed  Google Scholar 

  • Church, M. W., & Kaltenbach, J. A. (1997). Hearing, speech, language, and vestibular disorders in the fetal alcohol syndrome: a literature review. Alcoholism, Clinical and Experimental Research, 21(3), 495–512.

    PubMed  Google Scholar 

  • Coffman, B. A., Kodituwakku, P., Kodituwakku, E. L., Romero, L., Sharadamma, N. M., Stone, D., & Stephen, J. M. (2012). Primary visual response (M100) delays in adolescents with FASD as measured with MEG. Human Brain Mapping. doi:10.1002/hbm.22110.

    PubMed  PubMed Central  Google Scholar 

  • Conners, C. K. (2014). Conners continuous performance test, third edition (CPT-III). Toronto: Multi-Health Systems Inc.

    Google Scholar 

  • Cook, J. L., Green, C. R., Lilley, C. M., Anderson, S. M., Baldwin, M. E., Chudley, A. E., Conry, J. L., LeBlanc, N., Loock, C. A., Lutke, J. & Mallon, B. F. (2016). Fetal alcohol spectrum disorder: a guideline for diagnosis across the lifespan. Canadian Medical Association Journal, 188(3), pp.191-197.

  • Crocker, N., Riley, E. P., & Mattson, S. N. (2015). Visual-spatial abilities relate to mathematics achievement in children with heavy prenatal alcohol exposure. Neuropsychology, 29(1), 108–116. doi:10.1037/neu0000094.

    Article  PubMed  Google Scholar 

  • Crocker, N., Vaurio, L., Riley, E. P., & Mattson, S. N. (2009). Comparison of adaptive behavior in children with heavy prenatal alcohol exposure or attention-deficit/hyperactivity disorder. Alcoholism, Clinical and Experimental Research, 33(11), 2015–2023. doi:10.1111/j.1530-0277.2009.01040.x.

    Article  PubMed  PubMed Central  Google Scholar 

  • Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). The Delis-Kaplan Executive Function System: examiner’s manual. San Antonio: The Psychological Corporation.

    Google Scholar 

  • Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (1994). Manual for the California Verbal Learning Test Children’s Version. San Antonio: The Psychological Corporation.

    Google Scholar 

  • Doig, J., McLennan, J. D., & Gibbard, W. B. (2008). Medication effects on symptoms of attention-deficit/hyperactivity disorder in children with fetal alcohol spectrum disorder. Journal of Child and Adolescent Psychopharmacology, 18(4), 365–371.

    Article  PubMed  Google Scholar 

  • Doyle, L. R., & Mattson, S. N. (2015). Neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE): review of evidence and guidelines for assessment. Current Developmental Disorders Reports, 2(3), 175–186. doi:10.1007/s40474-015-0054-6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Drabble, L., Thomas, S., O’Connor, L., & Roberts, S. C. (2014). State responses to alcohol use and pregnancy: findings from the alcohol policy information system (APIS). Journal of Social Work Practice in the Addictions, 14(2), 191–206. doi:10.1080/1533256X.2014.900409.

    Article  PubMed  PubMed Central  Google Scholar 

  • Duquette, C., Stodel, E., Fullarton, S., & Hagglund, K. (2006). Persistence in high school: experiences of adolescents and young adults with fetal alcohol spectrum disorder. Journal of Intellectual and Developmental Disability, 31(4), 219–231.

    Article  PubMed  Google Scholar 

  • Finer, L. B., & Zolna, M. R. (2011). Unintended pregnancy in the United States: incidence and disparities, 2006. Contraception, 84(5), 478–485. doi:10.1016/j.contraception.2011.07.013.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fryer, S. L., McGee, C. L., Matt, G. E., Riley, E. P., & Mattson, S. N. (2007). Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure. Pediatrics, 119(3), e733–e741. doi:10.1542/peds.2006-1606.

    Article  PubMed  Google Scholar 

  • Gahagan, S., Sharpe, T. T., Brimacombe, M., Fry-Johnson, Y., Levine, R., Mengel, M., & Brenneman, G. (2006). Pediatricians’ knowledge, training, and experience in the care of children with fetal alcohol syndrome. Pediatrics, 118(3), e657–e668. doi:10.1542/peds.2005-0516.

    Article  PubMed  Google Scholar 

  • Glass, L., Graham, D. M., Akshoomoff, N., & Mattson, S. N. (2015). Cognitive factors contributing to spelling performance in children with prenatal alcohol exposure. Neuropsychology. doi:10.1037/neu0000185.

    PubMed Central  Google Scholar 

  • Glass, L., Ware, A. L., Crocker, N., Deweese, B. N., Coles, C. D., Kable, J. A., & CIFASD. (2013). Neuropsychological deficits associated with heavy prenatal alcohol exposure are not exacerbated by ADHD. Neuropsychology, 27(6), 713–724. doi:10.1037/a0033994.

    Article  PubMed  PubMed Central  Google Scholar 

  • Glass, L., Ware, A. L., & Mattson, S. N. (2014). Neurobehavioral, neurologic, and neuroimaging characteristics of fetal alcohol spectrum disorders. Handbook of Clinical Neurology, 125, 435–462. doi:10.1016/B978-0-444-62619-6.00025-2.

    Article  PubMed  Google Scholar 

  • Goh, P.K., Doyle, L.R., Glass, L., Jones, K.L., Riley, E.P., Coles, C.D., Hoyme, H.E., Kable, J.A., May, P.A., Kalberg, W.O., Sowell, E.R., Wozniak, J.R., Mattson, S.N., & CIFASD. (2016). Decision tree to identify children affected by prenatal alcohol exposure. Journal of Pediatrics, in press. doi:10.1016/j.jpeds.2016.06.047.

  • Goldschmidt, L., Richardson, G. A., Stoffer, D. S., Geva, D., & Day, N. L. (1996). Prenatal alcohol exposure and academic achievement at age six: a nonlinear fit. Alcoholism, Clinical and Experimental Research, 20(4), 763–770.

    Article  PubMed  Google Scholar 

  • Grant, T., Huggins, J., Connor, P., Pedersen, J. Y., Whitney, N., & Streissguth, A. (2004). A pilot community intervention for young women with fetal alcohol spectrum disorders. Community Mental Health Journal, 40(6), 499–511.

    Article  PubMed  Google Scholar 

  • Green, J. H. (2007). Fetal alcohol spectrum disorders: understanding the effects of prenatal alcohol exposure and supporting students. Journal of School Health, 77(3), 103–108. doi:10.1111/j.1746-1561.2007.00178.x.

    Article  PubMed  Google Scholar 

  • Green, P. P., McKnight-Eily, L. R., Tan, C. H., Mejia, R., & Denny, C. H. (2016). Vital signs: alcohol-exposed pregnancies—United States, 2011–2013. MMWR. Morbidity and Mortality Weekly Report, 65(4), 91–97. doi:10.15585/mmwr.mm6504a6.

  • Greenbaum, R. L., Stevens, S. A., Nash, K., Koren, G., & Rovet, J. (2009). Social cognitive and emotion processing abilities of children with fetal alcohol spectrum disorders: a comparison with attention deficit hyperactivity disorder. Alcoholism, Clinical and Experimental Research, 33(10), 1656–1670. doi:10.1111/j.1530-0277.2009.01003.x.

    Article  PubMed  Google Scholar 

  • Helder, E.J., Brooker, B., Kapitula, L.R., Goalen, B., & Gunnoe, M.J. (2016). Predictors and correlates of inattentive/overactive behaviors in internationally adopted children. Applied Neuropsychology Child, 1–15. doi:10.1080/21622965.2015.1038207.

  • Howell, K. K., Lynch, M. E., Platzman, K. A., Smith, G. H., & Coles, C. D. (2006). Prenatal alcohol exposure and ability, academic achievement, and school functioning in adolescence: a longitudinal follow-up. Journal of Pediatric Psychology, 31(1), 116–126. doi:10.1093/jpepsy/jsj029.

    Article  PubMed  Google Scholar 

  • Hoyme, H. E., May, P. A., Kalberg, W. O., Kodituwakku, P., Gossage, J. P., & Trujillo, P. M. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 Institute of Medicine criteria. Pediatrics, 115(1), 39–47.

    Article  PubMed  Google Scholar 

  • Hoyme, H. E., Kalberg, W. O., Elliott, A. J., Blankenship, J., Buckley, D., Marais, A. S., Manning, M. A., Robinson, L. K., Adam, M. P., Abdul-Rahman, O., & Jewett, T. (2016). Updated clinical guidelines for diagnosing fetal alcohol spectrum disorders. Pediatrics, 138, e20154256.

    Article  PubMed  Google Scholar 

  • Jan, J. E., Asante, K. O., Conry, J. L., Fast, D. K., Bax, M. C., Ipsiroglu, O. S., & Wasdell, M. B. (2010). Sleep health issues for children with FASD: clinical considerations. International Journal of Pediatrics, 2010. doi:10.1155/2010/639048.

  • Jirikowic, T., Carmichael Olson, H., & Kartin, D. (2008). Sensory processing, school performance, and adaptive behavior of young school-age children with fetal alcohol spectrum disorders. Physical & Occupational Therapy in Pediatrics, 28(2), 117–136.

    Article  Google Scholar 

  • Jones, K. L., Robinson, L. K., Bakhireva, L. N., Marintcheva, G., Storojev, V., Strahova, A., & Chambers, C. D. (2006). Accuracy of the diagnosis of physical features of fetal alcohol syndrome by pediatricians after specialized training. Pediatrics, 118(6), e1734–e1738. doi:10.1542/peds.2006-1037.

    Article  PubMed  Google Scholar 

  • Jones, K. L., & Smith, D. W. (1973). Recognition of the fetal alcohol syndrome in early infancy. Lancet, 302(7836), 999–1001.

    Article  PubMed  Google Scholar 

  • Kable, J. A., Taddeo, E., Strickland, D., & Coles, C. D. (2015). Community translation of the math interactive learning experience program for children with FASD. Research in Developmental Disabilities, 39, 1–11. doi:10.1016/j.ridd.2014.12.031.

    Article  PubMed  Google Scholar 

  • Kable, J. A., Coles, C. D., & Taddeo, E. (2007). Socio-cognitive habilitation using the math interactive learning experience program for alcohol-affected children. Alcoholism, Clinical and Experimental Research, 31(8), 1425–1434. doi:10.1111/j.1530-0277.2007.00431.x.

    Article  PubMed  Google Scholar 

  • Kable, J. A., O’Connor, M. J., Olson, H. C., Paley, B., Mattson, S. N., Anderson, S. M., & Riley, E. P. (2016). Neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE): proposed DSM-5 diagnosis. Child Psychiatry and Human Development, 47(2), 335–346. doi:10.1007/s10578-015-0566-7.

    Article  PubMed  Google Scholar 

  • Kaemingk, K. L., Mulvaney, S., & Halverson, P. T. (2003). Learning following prenatal alcohol exposure: performance on verbal and visual multitrial tasks. Archives of Clinical Neuropsychology, 18(1), 33–47.

    Article  PubMed  Google Scholar 

  • Kalberg, W. O., & Buckley, D. (2006). Educational planning for children with fetal alcohol syndrome. Annali dell’Istituto Superiore de Sanitá, 42(1), 58–66.

    Google Scholar 

  • Kalberg, W. O., & Buckley, D. (2007). FASD: what types of intervention and rehabilitation are useful? Neuroscience and Biobehavioral Reviews, 31(2), 278–285. doi:10.1016/j.neubiorev.2006.06.014.

    Article  PubMed  Google Scholar 

  • Kalberg, W. O., Provost, B., Tollison, S. J., Tabachnick, B. G., Robinson, L. K., Eugene Hoyme, H., & May, P. A. (2006). Comparison of motor delays in young children with fetal alcohol syndrome to those with prenatal alcohol exposure and with no prenatal alcohol exposure. Alcoholism, Clinical and Experimental Research, 30(12), 2037–2045. doi:10.1111/j.1530-0277.2006.00250.x.

    Article  PubMed  Google Scholar 

  • Kerns, K.A., Macoun, S., MacSween, J., Pei, J., & Hutchison, M. (2016). Attention and working memory training: a feasibility study in children with neurodevelopmental disorders. Applied Neuropsychology Child, 1–18. doi:10.1080/21622965.2015.1109513.

  • Kerns, K. A., Macsween, J., Vander Wekken, S., & Gruppuso, V. (2010). Investigating the efficacy of an attention training programme in children with foetal alcohol spectrum disorder. Developmental Neurorehabilitation, 13(6), 413–422. doi:10.3109/17518423.2010.511421.

    Article  PubMed  Google Scholar 

  • Kodituwakku, P. W., & Kodituwakku, E. L. (2011). From research to practice: an integrative framework for the development of interventions for children with fetal alcohol spectrum disorders. Neuropsychology Review, 21(2), 204–223. doi:10.1007/s11065-011-9170-1.

    Article  PubMed  Google Scholar 

  • Koren, G., Chudley, A., Loock, C., MacLeod, S. M., Orrbine, E., Rosales, T., & Sarkar, M. (2014). Screening and referral to identify children at risk for FASD: search for new methods 2006–2013. Journal of Population Therapeutics and Clinical Pharmacology, 21(2), e260–e265.

    PubMed  Google Scholar 

  • Korkman, M., Kirk, U., & Kemp, S. (2007). NEPSY-II 2nd ed. Administration manual. San Antonio: Harcourt Assessment.

    Google Scholar 

  • Loomes, C., Rasmussen, C., Pei, J., Manji, S., & Andrew, G. (2008). The effect of rehearsal training on working memory span of children with fetal alcohol spectrum disorder. Research in Developmental Disabilities, 29(2), 113–124. doi:10.1016/j.ridd.2007.01.001.

    Article  PubMed  Google Scholar 

  • Mattson, S. N., Crocker, N., & Nguyen, T. T. (2011). Fetal alcohol spectrum disorders: neuropsychological and behavioral features. Neuropsychology Review, 21(2), 81–101. doi:10.1007/s11065-011-9167-9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mattson, S. N., Gramling, L., Delis, D., Jones, K. L., & Riley, E. P. (1996). Global–local processing in children prenatally exposed to alcohol. Child Neuropsychology, 2(3), 165–175.

    Article  Google Scholar 

  • Mattson, S. N., & Riley, E. P. (2011). The quest for a neurobehavioral profile of heavy prenatal alcohol exposure. Alcohol Research and Health, 34(1), 51–55.

    PubMed  PubMed Central  Google Scholar 

  • Mattson, S. N., Roesch, S. C., Glass, L., Deweese, B. N., Coles, C. D., Kable, J. A., & Cifasd. (2013). Further development of a neurobehavioral profile of fetal alcohol spectrum disorders. Alcoholism, Clinical and Experimental Research, 37(3), 517–528. doi:10.1111/j.1530-0277.2012.01952.x.

    Article  PubMed  Google Scholar 

  • May, P. A., Baete, A., Russo, J., Elliott, A. J., Blankenship, J., Kalberg, W. O., & Hoyme, H. E. (2014). Prevalence and characteristics of fetal alcohol spectrum disorders. Pediatrics, 134(5), 855–866. doi:10.1542/peds.2013-3319.

    Article  PubMed  PubMed Central  Google Scholar 

  • May, P. A., Keaster, C., Bozeman, R., Goodover, J., Blankenship, J., Kalberg, W. O., & Hoyme, H. E. (2015). Prevalence and characteristics of fetal alcohol syndrome and partial fetal alcohol syndrome in a Rocky Mountain Region City. Drug and Alcohol Dependence, 155, 118–127. doi:10.1016/j.drugalcdep.2015.08.006.

    Article  PubMed  PubMed Central  Google Scholar 

  • McFarlane, A., & Rajani, H. (2007). Rural FASD diagnostic services model: Lakeland centre for fetal alcohol spectrum disorder. Canadian Journal of Clinical Pharmacology: Journal Canadien de Pharmacologie Clinique, 14(3), e301–e306.

    PubMed  Google Scholar 

  • McGee, C. L., Fryer, S. L., Bjorkquist, O. A., Mattson, S. N., & Riley, E. P. (2008). Deficits in social problem solving in adolescents with prenatal exposure to alcohol. American Journal of Drug and Alcohol Abuse, 34(4), 423–431. doi:10.1080/00952990802122630.

    Article  PubMed  Google Scholar 

  • Moore, E. M., & Riley, E. P. (2015). What happens when children with fetal alcohol spectrum disorders become adults? Current Developmental Disorders Reports, 2(3), 219–227. doi:10.1007/s40474-015-0053-7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nash, K., Stevens, S., Greenbaum, R., Weiner, J., Koren, G., & Rovet, J. (2015). Improving executive functioning in children with fetal alcohol spectrum disorders. Child Neuropsychology, 21(2), 191–209. doi:10.1080/09297049.2014.889110.

    Article  PubMed  Google Scholar 

  • Nguyen, T. T., Glass, L., Coles, C. D., Kable, J. A., May, P. A., Kalberg, W. O., & Cifasd. (2014). The clinical utility and specificity of parent report of executive function among children with prenatal alcohol exposure. Journal of the International Neuropsychological Society, 20(7), 704–716. doi:10.1017/S1355617714000599.

    Article  PubMed  PubMed Central  Google Scholar 

  • O’Connor, M. J., Frankel, F., Paley, B., Schonfeld, A. M., Carpenter, E., Laugeson, E. A., & Marquardt, R. (2006). A controlled social skills training for children with fetal alcohol spectrum disorders. Journal of Consulting and Clinical Psychology, 74(4), 639–648.

    Article  PubMed  Google Scholar 

  • Paolozza, A., Rasmussen, C., Pei, J., Hanlon-Dearman, A., Nikkel, S. M., Andrew, G., & Reynolds, J. N. (2014). Working memory and visuospatial deficits correlate with oculomotor control in children with fetal alcohol spectrum disorder. Behavioural Brain Research, 263, 70–79. doi:10.1016/j.bbr.2014.01.024.

    Article  PubMed  Google Scholar 

  • Peadon, E., Rhys-Jones, B., Bower, C., & Elliott, E.J. (2009). Systematic review of interventions for children with fetal alcohol spectrum disorders. BMC Pediatrics, 9(35). doi:10.1186/1471-2431-9-35.

  • Pei, J., Flannigan, K., Walls, L., & Rasmussen, C. (2016). Interventions for fetal alcohol spectrum disorder: meeting needs across the lifespan. International Journal of Neurorehabilitation, 3(1).

  • Pei, J. R., Rinaldi, C. M., Rasmussen, C., Massey, V., & Massey, D. (2008). Memory patterns of acquisition and retention of verbal and nonverbal information in children with fetal alcohol spectrum disorders. The Canadian Journal of Clinical Pharmacology, 15(1), e44–e56.

    PubMed  Google Scholar 

  • Premji, S., Benzies, K., Serrett, K., & Hayden, K. A. (2007). Research-based interventions for children and youth with a fetal alcohol spectrum disorder: revealing the gap. Child: Care, Health and Development, 33(4), 389–397. doi:10.1111/j.1365-2214.2006.00692.x. discussion 398–400.

    Google Scholar 

  • Rogers-Adkinson, D. L., & Stuart, S. K. (2007). Collaborative services: children experiencing neglect and the side effects of prenatal alcohol exposure. Language, Speech, and Hearing Services in Schools, 38(2), 149–156. doi:10.1044/0161-1461(2007/015).

    Article  PubMed  Google Scholar 

  • Rojmahamongkol, P., Cheema-Hasan, A., & Weitzman, C. (2015). Do pediatricians recognize fetal alcohol spectrum disorders in children with developmental and behavioral problems? Journal of Developmental and Behavioral Pediatrics, 36(3), 197–202. doi:10.1097/DBP.0000000000000146.

    Article  PubMed  Google Scholar 

  • Senturias, Y. S. (2014). Fetal alcohol spectrum disorders: an overview for pediatric and adolescent care providers. Current Problems in Pediatric and Adolescent Health Care, 44(4), 74–81. doi:10.1016/j.cppeds.2013.12.012.

    Article  PubMed  Google Scholar 

  • Shaffer, D., Fisher, P., Lucas, C. P., Dulcan, M. K., & Schwab-Stone, M. E. (2000). NIMH diagnostic interview schedule for children version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. The Journal of American Academy of Child Psychiatry, 39, 28–38.

    Article  Google Scholar 

  • Simmons, R. W., Madra, N. J., Levy, S. S., Riley, E. P., & Mattson, S. N. (2011). Co-regulation of movement speed and accuracy by children with heavy prenatal alcohol exposure. Perceptual and Motor Skills, 112(1), 172–182.

    Article  PubMed  PubMed Central  Google Scholar 

  • Simmons, R. W., Thomas, J. D., Levy, S. S., & Riley, E. P. (2006). Motor response selection in children with fetal alcohol spectrum disorders. Neurotoxicology and Teratology, 28(2), 278–285.

    Article  PubMed  Google Scholar 

  • Simmons, R. W., Thomas, J. D., Levy, S. S., & Riley, E. P. (2010). Motor response programming and movement time in children with heavy prenatal alcohol exposure. Alcohol, 44(4), 371–378. doi:10.1016/j.alcohol.2010.02.013.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sood, B., Delaney-Black, V., Covington, C., Nordstrom-Klee, B., Ager, J., Templin, T., & Sokol, R. J. (2001). Prenatal alcohol exposure and childhood behavior at age 6 to 7 years: I. dose–response effect. Pediatrics, 108(2), E34.

    Article  PubMed  Google Scholar 

  • Sparrow S.S., Cicchetti D.V., & Balla D.A. (2005). Vineland adaptive behavior scales—2nd edn. Pearson Assessments: Bloomington, MN. Pines, MN: American Guidance Service.

  • Strauss, E., Sherman, E. S., & Spreen, S. (2006). A compendium of neuropsychological tests: administration, norms, and commentary. Oxford, New York: Oxford University Press.

    Google Scholar 

  • Steinhausen, H.-C., & Spohr, H.-L. (1998). Long-term outcome of children with fetal alcohol syndrome: psychopathology, behavior and intelligence. Alcoholism, Clinical and Experimental Research, 22(2), 334–338.

    Article  PubMed  Google Scholar 

  • Streissguth, A. P., Aase, J. M., Clarren, S. K., Randels, S. P., LaDue, R. A., & Smith, D. F. (1991). Fetal alcohol syndrome in adolescents and adults. JAMA, 265(15), 1961–1967.

    Article  PubMed  Google Scholar 

  • Streissguth, A. P., Barr, H. M., Carmichael Olson, H., Sampson, P. D., Bookstein, F. L., & Burgess, D. M. (1994). Drinking during pregnancy decreases word attack and arithmetic scores on standardized tests: adolescent data from a population-based prospective study. Alcoholism, Clinical and Experimental Research, 18(2), 248–254.

    Article  PubMed  Google Scholar 

  • Streissguth, A. P., Barr, H. M., Kogan, J., & Bookstein, F. L. (1996). Final report: understanding the occurrence of secondary disabilities in clients with fetal alcohol syndrome (FAS) and fetal alcohol effects (FAE). Seattle: University of Washington Publication Services.

    Google Scholar 

  • Streissguth, A. P., Barr, H. M., Kogan, J., & Bookstein, F. L. (1997). Primary and secondary disabilities in fetal alcohol syndrome. In A. P. Streissguth, J. Kanter, et al. (Eds.), The challenge of fetal alcohol syndrome: overcoming secondary disabilities (pp. 25–39). Seattle: University of Washington Press.

    Google Scholar 

  • Streissguth, A. P., Bookstein, F. L., Barr, H. M., Sampson, P. D., O’Malley, K., & Young, J. K. (2004). Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects. Journal of Developmental and Behavioral Pediatrics, 25(4), 228–238.

    Article  PubMed  Google Scholar 

  • Thomas, G., Gonneau, G., Poole, N., & Cook, J. (2014). The effectiveness of alcohol warning labels in the prevention of fetal alcohol spectrum disorder: a brief review. International Journal of Alcohol and Drug Research, 3(1), 91–103. doi:10.7895/ijadr.vXiY.126.

    Article  Google Scholar 

  • Wechsler, D. (2015). Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V). Bloomington: Pearson.

    Google Scholar 

  • Wechsler, D. (2009). Wechsler Individual Achievement Test, Third Edition (WIAT-III). San Antonio: Psychological Corporation.

    Google Scholar 

  • Wells, A. M., Chasnoff, I. J., Schmidt, C. A., Telford, E., & Schwartz, L. D. (2012). Neurocognitive habilitation therapy for children with fetal alcohol spectrum disorders: an adaptation of the Alert Program(R). American Journal of Occupational Therapy, 66(1), 24–34. doi:10.5014/ajot.2012.002691.

    Article  PubMed  Google Scholar 

  • Wengel, T., Hanlon-Dearman, A. C., & Fjeldsted, B. (2011). Sleep and sensory characteristics in young children with fetal alcohol spectrum disorder. Journal of Developmental and Behavioral Pediatrics, 32(5), 384–392. doi:10.1097/DBP.0b013e3182199694.

    Article  PubMed  Google Scholar 

  • Willford, J. A., Richardson, G. A., Leech, S. L., & Day, N. L. (2004). Verbal and visuospatial learning and memory function in children with moderate prenatal alcohol exposure. Alcoholism, Clinical and Experimental Research, 28(3), 497–507.

    Article  PubMed  Google Scholar 

  • Willoughby, K. A., Sheard, E. D., Nash, K., & Rovet, J. (2008). Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood. Journal of the International Neuropsychological Society, 14(6), 1022–1033. doi:10.1017/S1355617708081368.

    Article  PubMed  Google Scholar 

  • Yan, A., Bell, E., & Racine, E. (2014). Ethical and social challenges in newborn screening for prenatal alcohol exposure. The Canadian Journal of Neurological Sciences, 41(1), 115–118.

    Article  PubMed  Google Scholar 

  • Zelner, I., Shor, S., Gareri, J., Lynn, H., Roukema, H., Lum, L., & Koren, G. (2010). Universal screening for prenatal alcohol exposure: a progress report of a pilot study in the region of Grey Bruce, Ontario. Therapeutic Drug Monitoring, 32(3), 305–310. doi:10.1097/FTD.0b013e3181dca381.

    Article  PubMed  Google Scholar 

  • Zelner, I., Shor, S., Lynn, H., Roukema, H., Lum, L., Eisinga, K., & Koren, G. (2012). Neonatal screening for prenatal alcohol exposure: assessment of voluntary maternal participation in an open meconium screening program. Alcohol, 46(3), 269–276. doi:10.1016/j.alcohol.2011.09.029.

    Article  PubMed  Google Scholar 

  • Zizzo, N., Di Pietro, N., Green, C., Reynolds, J., Bell, E., & Racine, E. (2013). Comments and reflections on ethics in screening for biomarkers of prenatal alcohol exposure. Alcoholism, Clinical and Experimental Research, 37(9), 1451–1455. doi:10.1111/acer.12115.

    Article  PubMed  Google Scholar 

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Acknowledgements

Preparation of this paper was supported by the National Institute on Alcohol Abuse and Alcoholism grants U01 AA014834 (Mattson) and F31 AA022261 (Glass). We thank the families and children affected by prenatal alcohol exposure for graciously participating in studies at the Center for Behavioral Teratology at San Diego State University.

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Correspondence to Sarah N. Mattson.

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This article does not contain any studies with human participants or animals performed by the author. The case study is a composite of cases seen by the first author.

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Glass, L., Mattson, S.N. Fetal Alcohol Spectrum Disorders: a Case Study. J Pediatr Neuropsychol 3, 114–135 (2017). https://doi.org/10.1007/s40817-016-0027-7

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