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The modified CKD-EPI equation may be not more accurate than CKD-EPI equation in determining glomerular filtration rate in Chinese patients with chronic kidney disease

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Abstract

Aim

To investigate the application of the new modified Chronic Kidney Disease Epidemiology Collaboration (mCKD-EPI) equation developed by Liu for the measurement of glomerular filtration rate (GFR) in Chinese patients with chronic kidney disease (CKD) and to evaluate whether this modified form is more accurate than the original one in clinical practice.

Methods

GFR was determined simultaneously by 3 methods: (a) 99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA) dual plasma sample clearance method (mGFR), which was used as the reference standard; (b) CKD-EPI equation (eGFRckdepi); (c) modified CKD-EPI equation (eGFRmodified). Concordance correlation and Passing-Bablok regression were used to compare the validity of eGFRckdepi and eGFRmodified. Bias, precision and accuracy were compared to identify which equation showed the better performance in determining GFR.

Results

A total of 170 patients were enrolled. Both eGFRckdepi and eGFRmodified correlated well with mGFR (concordance correlation coefficient 0.90 and 0.74, respectively) and the Passing-Bablok regression equation of eGFRckdepi and eGFRmodified against mGFR was mGFR = 0.37 + 1.04 eGFRckdepi and −49.25 + 1.74 eGFRmodified, respectively. In terms of bias, precision and 30 % accuracy, eGFRmodified showed a worse performance compared to eGFRckdepi, in the whole cohort.

Conclusions

The new modified CKD-EPI equation cannot replace the original CKD-EPI equation in determining GFR in Chinese patients with CKD.

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Authors and Affiliations

  1. Institute of Nuclear Medicine, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People’s Republic of China

    Peng Xie & Jian-min Huang

  2. Institute of Nephrology, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People’s Republic of China

    Ying Li

  3. Institute of Radiology, the Second Hospital, Hebei Medical University, No.215 Heping Road, Xinhua District, Shijiazhuang, Hebei, 050005, People’s Republic of China

    Huai-jun Liu

  4. Department of Research, The Third Hospital, Hebei Medical University, No.139 Ziqiang Road, Qiaoxi District, Shijiazhuang, Hebei, 050051, People’s Republic of China

    Yan Qu

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  1. Peng Xie
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  2. Jian-min Huang
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Correspondence to Huai-jun Liu.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Xie, P., Huang, Jm., Li, Y. et al. The modified CKD-EPI equation may be not more accurate than CKD-EPI equation in determining glomerular filtration rate in Chinese patients with chronic kidney disease. J Nephrol 30, 397–402 (2017). https://doi.org/10.1007/s40620-016-0307-4

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  • DOI: https://doi.org/10.1007/s40620-016-0307-4

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