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Physical excercise programs in CKD: lights, shades and perspectives: a position paper of the “Physical Exercise in CKD Study Group” of the Italian Society of Nephrology

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An Erratum to this article was published on 27 May 2015

Abstract

In the general population, moderate exercise is associated with several health benefits including a decreased risk of obesity, coronary heart disease, stroke, certain types of cancer and all-cause mortality. In chronic kidney disease (CKD), physical inability is an independent risk of death. Health benefits of regular exercise in CKD patients include improvements in functional and psychological measures such as aerobic and walking capacity and health-related quality of life. Nonetheless, in CKD patients exercise rehabilitation is not routinely prescribed. Renal patients are heterogeneous across the different stages of CKD so that the assessment of physical capability is mandatory for a correct exercise program prescription. To plan appropriate exercise programs in the CKD setting, targeted professional figures should be actively involved as many psychological or logistic barriers may hamper exercise implementation in these subjects. Different approaches, such as home exercise rehabilitation programs, supervised exercise training or in-hospital gym may theoretically be proposed. However, physical exercise should always be tailored to the individual capacity and comorbidities and each patient should ideally be involved in the decision-making process.

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References

  1. Dumith SC, Hallal PC, Reis RS, Kohl HW 3rd (2011) Worldwide prevalence of physical inactivity and its association with human development index in 76 countries. Prev Med 53(1–2):24–28

    Article  PubMed  Google Scholar 

  2. Owen N, Sparling PB, Healy GN, Dunstan DW, Matthews CE (2010) Sedentary behavior: emerging evidence for a new health risk. Mayo Clin Proc 85(12):1138–1141

    Article  PubMed Central  PubMed  Google Scholar 

  3. Gupta S, Rohatgi A, Ayers CR, Willis BL, Haskell WL, Khera A et al (2011) Cardiorespiratory fitness and classification of risk of cardiovascular disease mortality. Circulation 123(13):1377–1383

    Article  PubMed Central  PubMed  Google Scholar 

  4. Johansen KL (2007) Exercise in the end-stage renal disease population. J Am Soc Nephrol JASN 18(6):1845–1854

    Article  CAS  Google Scholar 

  5. Hsieh RL, Lee WC, Chang CH (2006) Maximal cardiovascular fitness and its correlates in ambulatory hemodialysis patients. Am J Kidney Dis Off J Natl Kidney Found 48(1):21–27

    Article  Google Scholar 

  6. Johansen KL, Chertow GM, Ng AV, Mulligan K, Carey S, Schoenfeld PY et al (2000) Physical activity levels in patients on hemodialysis and healthy sedentary controls. Kidney Int 57(6):2564–2570

    Article  CAS  PubMed  Google Scholar 

  7. Painter P (2005) Physical functioning in end-stage renal disease patients: update 2005. Hemodialysis international International Symposium on Home Hemodialysis 9(3):218–35

  8. Roshanravan B, Khatri M, Robinson-Cohen C, Levin G, Patel KV, de Boer IH et al (2012) A prospective study of frailty in nephrology-referred patients with CKD. Am J Kidney Dis Off J Natl Kidney Found 60(6):912–921

    Article  Google Scholar 

  9. Roshanravan B, Robinson-Cohen C, Patel KV, Ayers E, Littman AJ, de Boer IH et al (2013) Association between physical performance and all-cause mortality in CKD. J Am Soc Nephrol JASN 24(5):822–830

    Article  Google Scholar 

  10. Patel DR, Raj VM, Torres A (2009) Chronic kidney disease, exercise, and sports in children, adolescents, and adults. Phys Sportsmed 37(3):11–19

    Article  PubMed  Google Scholar 

  11. Padilla J, Krasnoff J, Da Silva M, Hsu CY, Frassetto L, Johansen KL et al (2008) Physical functioning in patients with chronic kidney disease. J Nephrol 21(4):550–559

    CAS  PubMed  Google Scholar 

  12. Brodin E, Ljungman S, Sunnerhagen KS (2008) Rising from a chair: a simple screening test for physical function in predialysis patients. Scand J Urol Nephrol 42(3):293–300

    Article  PubMed  Google Scholar 

  13. Kusek JW, Greene P, Wang SR, Beck G, West D, Jamerson K et al (2002) Cross-sectional study of health-related quality of life in African Americans with chronic renal insufficiency: the African American Study of Kidney Disease and Hypertension Trial. Am J Kidney Dis Off J Natl Kidney Found 39(3):513–524

    Article  Google Scholar 

  14. Heiwe S, Jacobson SH (2014) Exercise training in adults with CKD: a systematic review and meta-analysis. Am J Kidney Dis 64(3):383–393

    Article  PubMed  Google Scholar 

  15. Baggetta R, Bolignano D, Torino C, Manfredini F, Aucella F, Barilla A et al (2014) Fitness for entering a simple exercise program and mortality: a study corollary to the exercise introduction to enhance performance in dialysis (Excite) trial. Kidney Blood Press Res 39(2–3):197–204

    Article  PubMed  Google Scholar 

  16. Torino C, Manfredini F, Bolignano D, Aucella F, Baggetta R, Barilla A et al (2014) Physical performance and clinical outcomes in dialysis patients: a secondary analysis of the Excite trial. Kidney Blood Press Res 39(2–3):205–211

    Article  PubMed  Google Scholar 

  17. Bellizzi V, Cupisti A, Capitanini A, Calella P, D’Alessandro C (2014) Physical activity and renal transplantation. Kidney Blood Press Res 39(2–3):212–219

    Article  PubMed  Google Scholar 

  18. Balke B (1963) A simple field test for the assessment of physical fitness. Rep 63-6. [Report] Civil Aeromedical Research Institute. pp 1–8

  19. Harada ND, Chiu V, Stewart AL (1999) Mobility-related function in older adults: assessment with a 6-minute walk test. Arch Phys Med Rehabil 80(7):837–841

    Article  CAS  PubMed  Google Scholar 

  20. Jones CJ, Rikli RE, Beam WC (1999) A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Q Exerc Sport 70(2):113–119

    Article  CAS  PubMed  Google Scholar 

  21. Reboredo MM, Neder JA, Pinheiro BV, Henrique DM, Faria RS, Paula RB (2011) Constant work-rate test to assess the effects of intradialytic aerobic training in mildly impaired patients with end-stage renal disease: a randomized controlled trial. Arch Phys Med Rehabil 92(12):2018–2024

    Article  PubMed  Google Scholar 

  22. Cheema BS, Smith BC, Singh MA (2005) A rationale for intradialytic exercise training as standard clinical practice in ESRD. Am J Kidney Dis Off J Natl Kidney Found 45(5):912–916

    Article  Google Scholar 

  23. Robinson-Cohen C, Littman AJ, Duncan GE, Weiss NS, Sachs MC, Ruzinski J et al (2014) Physical activity and change in estimated GFR among persons with CKD. J Am Soc Nephrol JASN 25(2):399–406

    Article  CAS  Google Scholar 

  24. Boyce ML, Robergs RA, Avasthi PS, Roldan C, Foster A, Montner P et al (1997) Exercise training by individuals with predialysis renal failure: cardiorespiratory endurance, hypertension, and renal function. Am J Kidney Dis Off J Natl Kidney Found 30(2):180–192

    Article  CAS  Google Scholar 

  25. Clyne N (2004) The importance of exercise training in predialysis patients with chronic kidney disease. Clin Nephrol 61(Suppl 1):S10–S13

    PubMed  Google Scholar 

  26. Castaneda C, Gordon PL, Uhlin KL, Levey AS, Kehayias JJ, Dwyer JT et al (2001) Resistance training to counteract the catabolism of a low-protein diet in patients with chronic renal insufficiency. A randomized, controlled trial. Ann Intern Med 135(11):965–976

    Article  CAS  PubMed  Google Scholar 

  27. Deligiannis A, Kouidi E, Tourkantonis A (1999) Effects of physical training on heart rate variability in patients on hemodialysis. Am J Cardiol 84(2):197–202

    Article  CAS  PubMed  Google Scholar 

  28. DePaul V, Moreland J, Eager T, Clase CM (2002) The effectiveness of aerobic and muscle strength training in patients receiving hemodialysis and EPO: a randomized controlled trial. Am J Kidney Dis Off J Natl Kidney Found 40(6):1219–1229

    Article  CAS  Google Scholar 

  29. Kouidi EJ, Grekas DM, Deligiannis AP (2009) Effects of exercise training on noninvasive cardiac measures in patients undergoing long-term hemodialysis: a randomized controlled trial. Am J Kidney Dis Off J Natl Kidney Found 54(3):511–521

    Article  Google Scholar 

  30. Ouzouni S, Kouidi E, Sioulis A, Grekas D, Deligiannis A (2009) Effects of intradialytic exercise training on health-related quality of life indices in haemodialysis patients. Clin Rehabil 23(1):53–63

    Article  PubMed  Google Scholar 

  31. Tsuyuki K, Kimura Y, Chiashi K, Matsushita C, Ninomiya K, Choh K et al (2003) Oxygen uptake efficiency slope as monitoring tool for physical training in chronic hemodialysis patients. Ther Apher Dial Off Peer Rev J Int Soc Apher Jpn Soc Apher Jpn Soc Dial Ther 7(4):461–467

    Google Scholar 

  32. Johansen KL, Painter PL, Sakkas GK, Gordon P, Doyle J, Shubert T (2006) Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: a randomized, controlled trial. J Am Soc Nephrol JASN 17(8):2307–2314

    Article  CAS  Google Scholar 

  33. Kopple JD, Wang H, Casaburi R, Fournier M, Lewis MI, Taylor W et al (2007) Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle. J Am Soc Nephrol JASN 18(11):2975–2986

    Article  CAS  Google Scholar 

  34. Dobsak P, Homolka P, Svojanovsky J, Reichertova A, Soucek M, Novakova M et al (2012) Intra-dialytic electrostimulation of leg extensors may improve exercise tolerance and quality of life in hemodialyzed patients. Artif Organs 36(1):71–78

    Article  PubMed  Google Scholar 

  35. Fitts SS, Guthrie MR, Blagg CR (1999) Exercise coaching and rehabilitation counseling improve quality of life for predialysis and dialysis patients. Nephron 82(2):115–121

    Article  CAS  PubMed  Google Scholar 

  36. Koh KP, Fassett RG, Sharman JE, Coombes JS, Williams AD (2010) Effect of intradialytic versus home-based aerobic exercise training on physical function and vascular parameters in hemodialysis patients: a randomized pilot study. Am J Kidney Dis Off J Natl Kidney Found 55(1):88–99

    Article  Google Scholar 

  37. Matsumoto Y, Furuta A, Furuta S, Miyajima M, Sugino T, Nagata K et al (2007) The impact of pre-dialytic endurance training on nutritional status and quality of life in stable hemodialysis patients (Sawada study). Ren Fail 29(5):587–593

    Article  PubMed  Google Scholar 

  38. Molsted S, Eidemak I, Sorensen HT, Kristensen JH (2004) Five months of physical exercise in hemodialysis patients: effects on aerobic capacity, physical function and self-rated health. Nephron Clin Pract 96(3):c76–c81

    Article  PubMed  Google Scholar 

  39. Painter P, Moore G, Carlson L, Paul S, Myll J, Phillips W et al (2002) Effects of exercise training plus normalization of hematocrit on exercise capacity and health-related quality of life. Am J Kidney Dis Off J Natl Kidney Found 39(2):257–265

    Article  Google Scholar 

  40. Parsons TL, Toffelmire EB, King-VanVlack CE (2004) The effect of an exercise program during hemodialysis on dialysis efficacy, blood pressure and quality of life in end-stage renal disease (ESRD) patients. Clin Nephrol 61(4):261–274

    Article  CAS  PubMed  Google Scholar 

  41. van Vilsteren MC, de Greef MH, Huisman RM (2005) The effects of a low-to-moderate intensity pre-conditioning exercise programme linked with exercise counselling for sedentary haemodialysis patients in The Netherlands: results of a randomized clinical trial. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Renal Assoc 20(1):141–146

    Google Scholar 

  42. Capitanini A, Cupisti A, Mochi N, Rossini D, Lupi A, Michelotti G et al (2008) Effects of exercise training on exercise aerobic capacity and quality of life in hemodialysis patients. J Nephrol 21(5):738–743

    PubMed  Google Scholar 

  43. Lubrano R, Tancredi G, Bellelli E, Gentile I, Scateni S, Masciangelo R et al (2012) Influence of physical activity on cardiorespiratory fitness in children after renal transplantation. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Renal Assoc 27(4):1677–1681

    Google Scholar 

  44. Macdonald JH, Kirkman D, Jibani M (2009) Kidney transplantation: a systematic review of interventional and observational studies of physical activity on intermediate outcomes. Adv Chronic Kidney Dis 16(6):482–500

    Article  PubMed  Google Scholar 

  45. Thompson PD, Franklin BA, Balady GJ, Blair SN, Corrado D, Estes NA 3rd et al (2007) Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism and the Council on Clinical Cardiology. Circulation 115(17):2358–2368

    Article  PubMed  Google Scholar 

  46. Adams M, Williams A, Fell J (2009) Exercise in the fight against thrombosis: friend or foe? Semin Thromb Hemost 35(3):261–268

    Article  PubMed  Google Scholar 

  47. Kouidi E, Grekas D, Deligiannis A, Tourkantonis A (2004) Outcomes of long-term exercise training in dialysis patients: comparison of two training programs. Clin Nephrol 61(Suppl 1):S31–S38

    PubMed  Google Scholar 

  48. Kolko Labadens A, Lasseur C, Labat T, Trolonge S, Chauveau P (2014) [Physical activity in dialysis population: how and why to assess and establish a program?]. Nephrol Ther 10(3):151–158

    Article  PubMed  Google Scholar 

  49. KDIGO (2013) KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3(1):1–150

    Article  Google Scholar 

  50. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA et al (2007) Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation 116(9):1081–1093

    Article  PubMed  Google Scholar 

  51. Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren M et al (2012) European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 33(13):1635–1701

    Article  CAS  PubMed  Google Scholar 

  52. Painter P (2009) Implementing exercise: what do we know? Where do we go? Adv Chronic Kidney Dis 16(6):536–544

    Article  PubMed  Google Scholar 

  53. Greenwood SA, Lindup H, Taylor K, Koufaki P, Rush R, Macdougall IC et al (2012) Evaluation of a pragmatic exercise rehabilitation programme in chronic kidney disease. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Renal Assoc 27(Suppl 3):iii126–iii134

    Google Scholar 

  54. Haller MC, Vanholder R, Oberbauer R, Zoccali C, Van Biesen W (2014) Health economics and European Renal Best Practice-is it time to bring health economics into evidence-based guideline production in Europe? Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Renal Assoc 29(11):1994–1997

    Google Scholar 

  55. Li PK, Kwan BC, Ko GT, Chow KM, Leung CB, Szeto CC (2009) Treatment of metabolic syndrome in peritoneal dialysis patients. Perit Dial Int J Int Soc Perit Dial 29(Suppl 2):S149–S152

    CAS  Google Scholar 

  56. Malagoni AM, Catizone L, Mandini S, Soffritti S, Manfredini R, Boari B et al (2008) Acute and long-term effects of an exercise program for dialysis patients prescribed in hospital and performed at home. J Nephrol 21(6):871–878

    PubMed  Google Scholar 

  57. EXerCise Introduction To Enhance Performance in Dialysis (EXCITE). Available from: ClinicalTrials.gov NCT01255969

  58. Bulckaen M, Capitanini A, Lange S, Caciula A, Giuntoli F, Cupisti A (2011) Implementation of exercise training programs in a hemodialysis unit: effects on physical performance. J Nephrol 24(6):790–797

    Article  CAS  PubMed  Google Scholar 

  59. Greenwood SA, Naish P, Clark R, O’Connor E, Pursey VA, Macdougall IC et al (2014) Intra-dialytic exercise training: a pragmatic approach. J Ren Care 40(3):219–226

    Article  PubMed  Google Scholar 

  60. Kirkman DL, Mullins P, Junglee NA, Kumwenda M, Jibani MM, Macdonald JH (2014) Anabolic exercise in haemodialysis patients: a randomised controlled pilot study. J Cachexia Sarcopenia Muscle 5:199–207

    Article  PubMed Central  PubMed  Google Scholar 

  61. Giannaki CD, Stefanidis I, Karatzaferi C, Liakos N, Roka V, Ntente I et al (2011) The effect of prolonged intradialytic exercise in hemodialysis efficiency indices. ASAIO J 57(3):213–218

    Article  PubMed  Google Scholar 

  62. Maheshwari V, Samavedham L, Rangaiah GP, Loy Y, Ling LH, Sethi S et al (2012) Comparison of toxin removal outcomes in online hemodiafiltration and intra-dialytic exercise in high-flux hemodialysis: a prospective randomized open-label clinical study protocol. BMC Nephrol 13:156

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  63. Capitanini A, Lange S, D’Alessandro C, Salotti E, Tavolaro A, Baronti ME et al (2014) Dialysis exercise team: the way to sustain exercise programs in hemodialysis patients. Kidney Blood Press Res 39(2–3):129–133

    Article  CAS  PubMed  Google Scholar 

  64. Fuhrmann I, Krause R (2004) Principles of exercising in patients with chronic kidney disease, on dialysis and for kidney transplant recipients. Clin Nephrol 61(Suppl 1):S14–S25

    PubMed  Google Scholar 

  65. Carlson L, Carey S (1999) Staff responsibility to exercise. Adv Ren Replace Ther 6(2):172–180

    CAS  PubMed  Google Scholar 

  66. Bennett PN, Breugelmans L, Barnard R, Agius M, Chan D, Fraser D et al (2010) Sustaining a hemodialysis exercise program: a review. Semin Dial 23(1):62–73

    Article  PubMed  Google Scholar 

  67. Delgado C, Johansen KL (2010) Deficient counseling on physical activity among nephrologists. Nephron Clin Pract 116(4):c330–c336

    Article  PubMed  Google Scholar 

  68. Zheng J, You LM, Lou TQ, Chen NC, Lai DY, Liang YY et al (2010) Development and psychometric evaluation of the Dialysis patient-perceived Exercise Benefits and Barriers Scale. Int J Nurs Stud 47(2):166–180

    Article  PubMed  Google Scholar 

  69. Johansen KL, Sakkas GK, Doyle J, Shubert T, Dudley RA (2003) Exercise counseling practices among nephrologists caring for patients on dialysis. Am J Kidney Dis Off J Natl Kidney Found 41(1):171–178

    Article  Google Scholar 

  70. Workgroup KD (2005) K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients. Am J Kidney Dis Off J Natl Kidney Found 45(4 Suppl 3):S1–S153

    Google Scholar 

  71. Yee J (2009) Exercise in CKD: work it out. Adv Chronic Kidney Dis 16(6):405–406

    Article  PubMed  Google Scholar 

  72. Nelson ME, Rejeski WJ, Blair SN, Duncan PW, Judge JO, King AC et al (2007) Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Circulation 116(9):1094–1105

    Article  PubMed  Google Scholar 

  73. Aucella F, Gesuete A, Battaglia Y (2014) A “nephrological” approach to physical activity. Kidney Blood Press Res 39(2–3):189–196

    Article  PubMed  Google Scholar 

  74. Aucella F, Valente GL, Catizone L (2014) The role of physical activity in the CKD setting. Kidney Blood Press Res 39(2–3):97–106

    Article  PubMed  Google Scholar 

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Aucella, F., Battaglia, Y., Bellizzi, V. et al. Physical excercise programs in CKD: lights, shades and perspectives: a position paper of the “Physical Exercise in CKD Study Group” of the Italian Society of Nephrology. J Nephrol 28, 143–150 (2015). https://doi.org/10.1007/s40620-014-0169-6

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