Abstract
Introduction
Following traumatic brain injury (TBI), there may be persistent pituitary deficits despite the presence of normal conventional magnetic resonance (MR) images. Little is known about the association of microstructural changes in the pituitary with pituitary function in TBI patients with normal appearing brain on conventional MR images. Our aim was to quantify changes in pituitary apparent diffusion coefficient (ADC) of normal appearing brain in human traumatic brain injury.
Methods
Forty-two patients admitted with a diagnosis of mild head injury having normal appearing brain imaging were scanned at 7 days after injury using a quantitative echo planar imaging acquisition to obtain ADC parametric map. Mean pituitary ADC values were compared with a control group (n = 30).
Results
The TBI group showed a significant decrease in pituitary ADC compared to the controls. Furthermore, the mean ADC was much less in TBI patients with pituitary dysfunction compared to those with normal pituitary function. There was also a correlation between the development of pituitary dysfunction and decreasing ADC (r = 0.82, P<0.01).
Conclusion
Our findings suggest that pituitary ADC is a sensitive and independent marker of pituitary damage following traumatic insult, which is useful to detect the microstructural damage in pituitary in normal appearing brain.
References
Krahulik D, Zapletalova J, Frysak Z et al (2010) Dysfunction of hypothalamic–hypophysial axis after traumatic brain injury in adults. J Neurosurg 113:581–584
Schneider HJ, Sämann PG, Schneider M et al (2007) Pituitary imaging abnormalities in patients with and without hypopituitarism after traumatic brain injury. J Endocrinol Invest 30:RC9–RC12
Benson CM, Yong GB (2013) New guidelines for the initial management of head injury. BMC Med 11:51
Kim JJ, Gean AD (2011) Imaging for the diagnosis and management of traumatic brain injury. Neurotherapeutics 8:39–53
Lescot T, Fulla-Oller L, Po C et al (2010) Temporal and regional changes after focal traumatic brain injury. J Neurotrauma 27:85–94
Brandstack N, Kurki T, Hiekkanen H et al (2011) Diffusivity of normal-appearing tissue in acute traumatic brain injury. Clin Neuroradiol 21:75–82
Wu TC, Wilde EA, Bigler ED et al (2010) Longitudinal changes in the corpus callosum following pediatric traumatic brain injury. Dev Neurosci 32:361–373
Wilde EA, Ayoub KW, Bigler ED et al (2012) Diffusion tensor imaging in moderate-to-severe pediatric traumatic brain injury: changes within an 18 month post-injury interval. Brain Imaging Behav 6:404–416
Mac Donald CL, Dikranian K, Bayly P et al (2007) Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury. J Neurosci 27:11869–11876
Desai V, Shen Q, Duong TQ (2012) Incorporating ADC temporal profiles to predict ischemic tissue fate in acute stroke. Brain Res 1458:86–92
Hori M, Motosugi U, Fatima Z et al (2011) A comparison of mean displacement values using high b-value Q-space diffusion-weighted MRI with conventional apparent diffusion coefficients in patients with stroke. Acad Radio 18:837–841
Kibayashi K, Shimada R, Nakao IK et al (2012) Analysis of pituitary lesions in fatal closed head injury. Am J Forensic Med Pathol 33:206–210
Acknowledgments
This study was supported by a Grant for the Promotion of Science, the Ministry of Health, Pudong New area, Shanghai China (Grant PW2011A-13).
Conflict of interest
All authors declared no conflicts of interest.
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Zheng, P., He, B. & Tong, W.S. Decrease in pituitary apparent diffusion coefficient in normal appearing brain correlates with hypopituitarism following traumatic brain injury. J Endocrinol Invest 37, 309–312 (2014). https://doi.org/10.1007/s40618-014-0059-8
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DOI: https://doi.org/10.1007/s40618-014-0059-8