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Prevalent fragility fractures as risk factor for skeletal muscle function deficit and dysmobility syndrome in post-menopausal women

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Abstract

Background

Fragility fractures are a major burden for health and social care in elderly people. In order to identify earlier the “frail elders”, new concepts of “dysmobility syndrome” and skeletal muscle function deficit (SMFD), including sarcopenia, osteoporosis, obesity, and mobility limitation, leading to a higher risk of fractures, have been recently introduced. There are very few studies investigating the association between fragility fractures and both the dysmobility syndrome and the SMFD.

Aims

The objective of our study is to investigate the role of previous fragility fractures as a risk factor in determining the dysmobility syndrome and/or the SMFD in post-menopausal women.

Methods

In this case–control study, we retrospectively examined data from the medical records of post-menopausal women aged 50 or older. We divided the study population in two groups. The first group includes women with a previous fragility fracture (cases) and the other group includes women without any previous osteoporotic fracture (controls). We identified the subjects with “dysmobility syndrome”, “dynapenic SMFD”, “sarcopenic SMFD”, and “mixed SMFD” in both groups. Data collected refer to a 6-month period.

Results

We retrieved data of 121 post-menopausal women, 77 (63.64 %) had already sustained a fragility fracture at any site (cases). The risk for dysmobility syndrome was significantly higher (adjusted OR for age and serum 25-OH vitamin D3 of 2.46) in the cases compared with the controls.

Discussion and conclusions

An early diagnosis of conditions limiting mobility, including dysmobility syndrome, might be useful to identify, among patients with osteoporotic fractures, those who might have a higher risk of a new fragility fracture.

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Authors and Affiliations

  1. Department of Medical and Surgical Specialties and Dentistry, Second University of Naples, Naples, Italy

    Giovanni Iolascon, Antimo Moretti & Maria Teresa Giamattei

  2. Department of Movement, Human and Health Sciences, Unit of Endocrinology, University of Rome “Foro Italico”, Largo Lauro De Bosis 15, 00195, Rome, Italy

    Silvia Migliaccio

  3. Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy

    Francesca Gimigliano

Authors
  1. Giovanni Iolascon
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  2. Antimo Moretti
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  3. Maria Teresa Giamattei
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  4. Silvia Migliaccio
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  5. Francesca Gimigliano
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Corresponding author

Correspondence to Giovanni Iolascon.

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Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest. No funding was received in support of this study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/ or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Iolascon, G., Moretti, A., Giamattei, M.T. et al. Prevalent fragility fractures as risk factor for skeletal muscle function deficit and dysmobility syndrome in post-menopausal women. Aging Clin Exp Res 27 (Suppl 1), 11–16 (2015). https://doi.org/10.1007/s40520-015-0417-1

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  • DOI: https://doi.org/10.1007/s40520-015-0417-1

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