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Network-Guided Transcranial Magnetic Stimulation for Depression

  • Neuromodulation (S Taylor, Section Editor)
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Abstract

Purpose of Review

First, we will identify candidate predictive biomarkers of antidepressant response of TMS based on the neuroimaging literature. Next, we will review the effects of TMS on networks involved in depression. Finally, we will discuss ways in which our current understanding of network engagement by TMS may be used to optimize its antidepressant effect.

Recent Findings

The past few years has seen significant interest in the antidepressant mechanisms of TMS. Studies using functional neuroimaging and neurochemical imaging have demonstrated engagement of networks known to be important in depression. Current evidence supports a model whereby TMS normalizes network function gradually over the course of several treatments. This may, in turn, mediate its antidepressant effect.

Summary

One strategy to optimize the antidepressant effect of TMS is to more precisely target networks relevant in depression. We propose methods to achieve this using functional and neurochemical imaging.

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References

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Authors and Affiliations

  1. Department of Psychiatry, Weill Cornell Medical College, New York, NY, 10065, USA

    Marc J. Dubin, Conor Liston, Irena Ilieva & Faith M. Gunning

  2. Feil Family Mind and Brain Institute, Weill Cornell Medical College, New York, NY, 10065, USA

    Marc J. Dubin & Conor Liston

  3. Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY, 10065, USA

    Conor Liston

  4. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA

    Michael A. Avissar

  5. Division of Experimental Therapeutics, New York State Psychiatric Institute, New York, NY, USA

    Michael A. Avissar

  6. Institute of Geriatric Psychiatry, Weill Cornell Medical College, New York, NY, 10065, USA

    Irena Ilieva & Faith M. Gunning

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  1. Marc J. Dubin
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Correspondence to Marc J. Dubin.

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Conflict of Interest

Dr. Marc J. Dubin reports materials transfer to complete studies of TMS for depression from Neuronetics, Inc., grant funding for a clinical trial of Low Field Magnetic Stimulation for Major Depression from TAL Medical, Inc., outside the submitted work. Dr. Conor Liston, Dr. Michael A. Avissar, Dr. Irena Ilieva, and Dr. Faith M. Gunning declare that they have no conflicts of interest. Dr. Faith Gunning is supported by NIMH grant R01MH097735 PI.

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Dubin, M.J., Liston, C., Avissar, M.A. et al. Network-Guided Transcranial Magnetic Stimulation for Depression. Curr Behav Neurosci Rep 4, 70–77 (2017). https://doi.org/10.1007/s40473-017-0108-7

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